Equine YKL-40 antibody and antigen (recombinant protein)

Diagnostic anti-Equine YKL-40 antibodies pairs and antigen for animal health (animal Equine/Horse Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Equine disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-EQU-YKL-40-Ag01Equine YKL-40$3090.00
GMP-EQU-YKL-40-Ab01Anti-Equine YKL-40 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-YKL-40-Ab02Anti-Equine YKL-40 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-YKL-40-Ab03Anti-Equine YKL-40 human monoclonal antibody (mAb)$3090.00
GMP-EQU-YKL-40-Ab04Anti-Equine YKL-40 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-EQU-YKL-40-Ag01
Product NameEquine YKL-40
Target/BiomarkerEquine YKL-40
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Equine YKL-40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in YKL-40 level test of animal Equine/Horse with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsEquine YKL-40
Product descriptionRecombinant Equine YKL-40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-YKL-40-Ab01,GMP-EQU-YKL-40-Ab02
Target/BiomarkerEquine YKL-40
Product NameAnti-Equine YKL-40 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Equine YKL-40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine YKL-40 antibodies in Equine YKL-40 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product descriptionAnti-Equine YKL-40 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine YKL-40 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-YKL-40-Ab03,GMP-EQU-YKL-40-Ab04
Target/BiomarkerEquine YKL-40
Product NameAnti-Equine YKL-40 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Equine YKL-40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine YKL-40 antibodies in Equine YKL-40 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product descriptionAnti-Equine YKL-40 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Equine YKL-40, a glycoprotein with a molecular weight of approximately 40 kDa, emerges as a captivating figure in the intricate realm of equine immune responses and tissue dynamics. While it bears structural resemblance to chitinases, it distinguishes itself by its absence of chitinase activity. Its presence is pervasive in various equine tissues, with prominent expression in the liver, kidneys, lungs, and immune cells.

    Structurally, Equine YKL-40 is characterized by its unique chitin-binding domain, which suggests involvement in tissue remodeling and repair. The glycosylation of this protein enhances its stability and modulates its functions, particularly within the context of inflammation.

    The regulation of Equine YKL-40 expression is tightly orchestrated, with immune cells, including macrophages and neutrophils, being significant contributors. These cells are activated in response to inflammatory cues, prompting YKL-40 production. This induction underscores its role as a pro-inflammatory mediator and a sentinel of immune system activation.

    Beyond its role in immune responses, Equine YKL-40 is intricately linked to tissue remodeling processes. In conditions characterized by tissue injury and repair, such as wound healing and fibrosis, YKL-40's interactions with fibroblasts and epithelial cells gain prominence. It appears to modulate cellular activities associated with extracellular matrix turnover and tissue restructuring.



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