Feline AD7c-NTP antibody and antigen (recombinant protein)

Diagnostic anti-Feline AD7c-NTP antibodies pairs and antigen for animal health (animal Cat/Feline Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-FEL-AD7c-NTP-Ag01Feline AD7c-NTP$3090.00
GMP-FEL-AD7c-NTP-Ab01Anti-Feline AD7c-NTP mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-AD7c-NTP-Ab02Anti-Feline AD7c-NTP mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-AD7c-NTP-Ab03Anti-Feline AD7c-NTP human monoclonal antibody (mAb)$3090.00
GMP-FEL-AD7c-NTP-Ab04Anti-Feline AD7c-NTP human monoclonal antibody (mAb)$3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-FEL-AD7c-NTP-Ag01
Product NameFeline AD7c-NTP
Target/BiomarkerFeline AD7c-NTP
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Feline AD7c-NTP antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AD7c-NTP level test of animal Cat/Feline with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsFeline AD7c-NTP
Product descriptionRecombinant Feline AD7c-NTP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-AD7c-NTP-Ab01,GMP-FEL-AD7c-NTP-Ab02
Target/BiomarkerFeline AD7c-NTP
Product NameAnti-Feline AD7c-NTP mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Feline AD7c-NTP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline AD7c-NTP antibodies in Feline AD7c-NTP level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline AD7c-NTP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline AD7c-NTP antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-AD7c-NTP-Ab03,GMP-FEL-AD7c-NTP-Ab04
Target/BiomarkerFeline AD7c-NTP
Product NameAnti-Feline AD7c-NTP human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Feline AD7c-NTP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline AD7c-NTP antibodies in Feline AD7c-NTP level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline AD7c-NTP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Feline AD-associated Neuronal Thread Protein (AD7c-NTP) stands as a pivotal character in the intricate narrative of feline neurodegeneration. Structurally akin to its human counterpart, AD7c-NTP is a neuronal protein intricately involved in the development of neurofibrillary tangles—a hallmark of cognitive dysfunction shared with Alzheimer's disease (AD).

    The journey of AD7c-NTP begins within the feline brain, where it participates in the complex choreography of neurofibrillary tangle formation. These tangles, characterized by their twisted filaments primarily composed of AD7c-NTP, are emblematic of cognitive dysfunction and memory impairment in cats. This phenomenon mirrors the neurofibrillary tangles seen in humans with AD, underscoring the evolutionary conservation of neurodegenerative processes.

    At a molecular level, the aggregation of AD7c-NTP and its association with other proteins give rise to the neurofibrillary tangles that disrupt the normal architecture and function of neurons. This disruption leads to neuronal degeneration and synapse loss, ultimately manifesting as the cognitive deficits observed in cats afflicted with feline cognitive dysfunction syndrome (FCDS).



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