Feline S100-A9 antibody and antigen (recombinant protein)

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Diagnostic anti-Feline S100-A9 antibodies pairs and antigen for animal health (animal Cat/Feline inflammatory bowel disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Size： 1mg | 10mg | 100mg

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Target/Biomarker Information

S100-A9 in cats (felines) is a remarkable biomarker that transcends its status to become a pivotal player in feline health, inflammation, and immunity. As a member of the S100 protein family, this calcium-binding protein holds multifaceted roles in various cellular processes, particularly those related to inflammation and immune responses.

S100-A9, also known as calgranulin B, takes center stage in feline physiology, primarily produced by neutrophils and monocytes. Its significance lies in its ability to form a heterodimeric complex with S100-A8, collectively known as S100A8/A9 or calprotectin. This complex plays a pivotal role in the innate immune system's repertoire, serving as a key participant in immune regulation, host defense, and tissue homeostasis.

The release of S100A8/A9 is orchestrated by activated neutrophils and monocytes, in response to inflammatory cues. This release into the extracellular environment initiates a cascade of events, where S100A8/A9 emerges as a potent pro-inflammatory mediator. Its functions include the recruitment of immune cells to sites of infection or injury, facilitating phagocytosis, and amplifying immune responses. Such versatile roles underscore its significance in feline immune defenses.

However, S100-A9's influence extends beyond inflammation, encompassing a spectrum of cellular processes. It plays a pivotal role in cell adhesion, differentiation, and tissue repair. As a damage-associated molecular pattern (DAMP) molecule, S100-A9 serves as a sentinel, triggering immune responses when confronted with tissue damage or infection. This multifunctional nature highlights its significance in feline physiology, where it acts as a versatile player in immune regulation and tissue homeostasis.

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