Feline TIMP-1 antibody and antigen (recombinant protein)

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Product information

Size： 1mg | 10mg | 100mg

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-FEL-TIMP-1-Ag01	Recombinant Feline TIMP-1 protein	3090
GMP-FEL-TIMP-1-Ab01	Anti-Feline TIMP-1 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-TIMP-1-Ab02	Anti-Feline TIMP-1 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-TIMP-1-Ab03	Anti-Feline TIMP-1 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-TIMP-1-Ab04	Anti-Feline TIMP-1 mouse monoclonal antibody (mAb)	1953	20%	1562.4

Shipping Costs: $360–$760
Antibodies: $360 Antigens: $760 (Elevated cost due to antigen heterogeneity, post-translational modifications, structural complexity, and specialized handling.)

Product Description

Cat No. of Products	GMP-FEL-TIMP-1-Ag01
Product Name	Recombinant Feline TIMP-1 protein
Target/Biomarker	Feline Matrix Metalloproteinase Inhibitor-1 (TIMP-1)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Matrix Metalloproteinase Inhibitor-1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in TIMP-1 level test of animal Cat/Feline with coronary artery stenosis, coronary artery lesions.
Tag	His
Products description	Recombinant Feline TIMP-1 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-TIMP-1-Ab01, GMP-FEL-TIMP-1-Ab02, GMP-FEL-TIMP-1-Ab03, GMP-FEL-TIMP-1-Ab04
Product Name	Anti-Feline TIMP-1 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Matrix Metalloproteinase Inhibitor-1 (TIMP-1)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Anti-Feline Matrix Metalloproteinase Inhibitor-1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in TIMP-1 level test of animal Cat/Feline with coronary artery stenosis, coronary artery lesions.
Tag	mFc
Products description	Anti-Feline TIMP-1 mouse monoclonal antibody (mAb) was expressed in CHO - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

TIMP-1, also known as Tissue Inhibitor of Metalloproteinases-1, is a specific biomarker found in feline species. It belongs to the TIMP family, comprising TIMP-1, TIMP-2, TIMP-3, and TIMP-4. These biomarkers are endogenous inhibitors of matrix metalloproteinases (MMPs), enzymes responsible for the degradation of the extracellular matrix (ECM). Among the members of the TIMP family, TIMP-1 is extensively studied and characterized. It plays a crucial role in maintaining ECM homeostasis and regulating tissue remodeling processes in cats. TIMP-1 exerts its inhibitory effect on MMPs by forming complexes with them, preventing their enzymatic activity and subsequently controlling ECM turnover. The balance between MMPs and TIMPs is essential for normal physiological functions, such as wound healing, angiogenesis, and immune response modulation. Aberrant regulation of TIMP-1 expression has been implicated in various diseases, including cancer, fibrosis, cardiovascular disorders, and neurodegenerative conditions. In these pathological states, dysregulated TIMP-1 levels can disrupt the delicate ECM balance, leading to tissue damage, disease progression, and impaired healing processes. Therefore, quantifying TIMP-1 levels in feline models provides valuable insights into ECM dynamics, tissue remodeling, and associated diseases. Various techniques, such as ELISA, immunohistochemistry, or molecular analysis, can be employed to measure TIMP-1 concentrations in biological samples like serum, plasma, or tissues. Understanding the distinct properties and functions of TIMP-1 in cats contributes to improving diagnostic tools, therapeutic strategies, and overall feline health management.

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