Feline VDBP antibody and antigen (recombinant protein)

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Diagnostic anti-Feline VDBP antibodies pairs and antigen for animal health (animal Cat/Feline liver failure, type I diabetes, cystic fibrosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Size： 1mg | 10mg | 100mg

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Target/Biomarker Information

Vitamin D Binding Protein (VDBP) in cats, or felines, occupies a pivotal position in the intricate tapestry of feline physiology, orchestrating the complex symphony of vitamin D metabolism and transportation. This multifunctional protein, predominantly synthesized in the liver, plays an indispensable role in ensuring the efficient utilization of vitamin D, a vital fat-soluble nutrient for feline health.

VDBP's primary role is that of a guardian of vitamin D, a crucial component of feline well-being. Vitamin D is a master regulator, orchestrating calcium homeostasis, bone health, and immune system function. However, this fat-soluble vitamin comes with unique transportation challenges. Vitamin D doesn't readily dissolve in water, making it challenging to navigate the aqueous environment of the bloodstream. Herein lies the remarkable function of VDBP.

VDBP, acting as a faithful chaperone, binds to vitamin D and its metabolites, including calcidiol and calcitriol. This binding not only enhances the solubility of these compounds but also ensures their safe passage through the bloodstream to reach their intended destinations. These destinations include the intestines, where vitamin D is essential for calcium absorption, as well as the bones, where it supports bone mineralization, and immune cells, where it modulates the immune response.

The importance of VDBP's transport function cannot be overstated. In the intestines, it facilitates calcium absorption, a cornerstone of skeletal health in cats. Calcium is a fundamental mineral for bone strength, muscle function, and overall body integrity, and its regulation is intricately tied to vitamin D. VDBP ensures that vitamin D is available in sufficient quantities to uphold calcium homeostasis, safeguarding bone integrity and overall feline well-being.

Moreover, vitamin D plays a pivotal role in immune system function. It acts as an immunomodulator, helping to regulate the immune response. A deficiency in vitamin D can compromise the feline immune system, potentially leading to increased susceptibility to infections and other diseases.

Beyond its role in vitamin D transport, VDBP has a fascinating facet - its immunomodulatory properties. VDBP can interact with immune cells and various cytokines, potentially influencing the immune response in cats. This aspect of VDBP's function broadens its significance beyond vitamin D regulation and invites exploration into its broader impact on feline health and immune-related conditions.

The regulation of VDBP synthesis adds yet another layer of complexity. It is influenced by several factors, including vitamin D status, hormones, and genetic factors. When vitamin D levels are low, the production of VDBP increases, enhancing vitamin D transport and utilization. Conversely, when vitamin D levels are elevated, VDBP levels may decrease, serving as a regulatory mechanism to prevent excessive vitamin D activity and potential toxicity.

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