Feline proBNP antibody and antigen (recombinant protein) GMP-FEL-proBNP

Diagnostic anti-Feline proBNP antibodies pairs and antigen for animal health (animal Cat/Feline intrinsic cardiac dysfunction) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Size： 1mg | 10mg | 100mg

Catalog No. Description US $ Price (per mg) First Order Discount First Order Discount Price
GMP-FEL-proBNP-Ag01 Recombinant Feline proBNP protein 3090
GMP-FEL-proBNP-Ab01 Anti-Feline proBNP mouse monoclonal antibody (mAb) 1953 20% 1562.4
GMP-FEL-proBNP-Ab02 Anti-Feline proBNP mouse monoclonal antibody (mAb) 1953 20% 1562.4
GMP-FEL-proBNP-Ab03 Anti-Feline proBNP mouse monoclonal antibody (mAb) 1953 20% 1562.4
GMP-FEL-proBNP-Ab04 Anti-Feline proBNP mouse monoclonal antibody (mAb) 1953 20% 1562.4

Shipping Costs: $360–$760
Antibodies: $360 Antigens: $760 (Elevated cost due to antigen heterogeneity, post-translational modifications, structural complexity, and specialized handling.)



Product Description

Cat No. of Products GMP-FEL-proBNP-Ag01
Product Name Recombinant Feline proBNP protein
Target/Biomarker Feline pro B-type natriuretic peptide (proBNP)
Expression platform E.coli
Bioactivity validation Anti-Feline pro B-type natriuretic peptide antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in proBNP level test of animal Cat/Feline with intrinsic cardiac dysfunction.
Tag His
Products description Recombinant Feline proBNP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution PBS liquid / Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products GMP-FEL-proBNP-Ab01, GMP-FEL-proBNP-Ab02, GMP-FEL-proBNP-Ab03, GMP-FEL-proBNP-Ab04
Product Name Anti-Feline proBNP mouse monoclonal antibody (mAb)
Target/Biomarker Feline pro B-type natriuretic peptide (proBNP)
Expression platform CHO
Bioactivity validation Recombinant Feline pro B-type natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies in proBNP level test of animal Cat/Feline with intrinsic cardiac dysfunction.
Tag mFc
Products description Anti-Feline proBNP mouse monoclonal antibody (mAb) was expressed in CHO.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    Detection performance and stability evaluation of GeneMedi's anti-Feline NT-proBNP antibodies

    GeneMedi's anti-Feline NT-proBNP antibody pairs offer excellent sensitivity, specificity, and stability, making them ideal for diagnostic assay development. They enable reliable detection across a broad concentration range with low EC50 and detection limits, while showing minimal cross-reactivity with canine and human NT-proBNP. Stability tests under diverse storage conditions confirm their robustness for both research and diagnostic applications.

    Fig 1. Detection performance and stability evaluation of GeneMedi's anti-Feline NT-proBNP antibodies

    A–B. Detection curves of feline NT-proBNP. The low EC50 values across multiple combinations highlight the high sensitivity of these antibodies for feline NT-proBNP detection. C. Analytical performance of antibody pairs.
    D. Specificity assessment across species. Direct ELISA analysis confirms strong binding to feline NT-proBNP while showing negligible or significantly reduced reactivity to canine and human NT-proBNP, demonstrating high assay specificity.
    E. Stability testing under different storage conditions. Antibodies maintain consistent EC50 values after two months at 37 °C (lyophilized or liquid) and −80 °C, confirming excellent stability for long-term storage and reliable performance under diverse conditions.

    cTnI validation

    Click to Zoom

    GeneMedi's anti-Feline NT-proBNP antibody pairs demonstrate outstanding clinical detection performance across diverse Fc platforms.

    GeneMedi's NT-proBNP immunoassay antibody pairs demonstrate outstanding performance in clinical sample detection, effectively differentiating between healthy and HCM feline plasma with high sensitivity and robust signal output.

    The pairs exhibit excellent affinity and specificity across multiple configurations, including both human Fc-based and mouse Fc-tagged versions, consistently showing strong dose-response relationships and clear discrimination between sample types. This versatility and reliability make them ideal for cardiovascular disease diagnostic assays, particularly in veterinary and translational research settings.

    Fig 2. GeneMedi's anti-Feline NT-proBNP antibody pairs demonstrate outstanding clinical detection performance across diverse Fc platforms.

    A. NT-proBNP Antibody Pairs with Human Fc Tags. Human Fc-based antibody pairs exhibit significantly elevated NT-proBNP detection levels in HCM cat plasma versus healthy controls, with a strong dose-response relationship and high signal intensity confirming excellent affinity and specificity.
    B. NT-proBNP Antibody Pairs with Mouse Fc Tags. Mouse Fc-tagged pairs (e.g., Coating Ab: Ab01 mFc; Detection Ab: Ab02/06 mFc) similarly distinguish healthy from HCM feline samples, showing high signal in diseased cohorts and demonstrating consistent versatility and robustness across Fc platforms.

    cTnI validation

    Click to Zoom

    Click to get more Data / Case study about the product.



    Target/Biomarker information

    Feline proBNP, or pro-brain natriuretic peptide, is an intriguing biomarker exclusive to cats. It is a prohormone consisting of 108 amino acids, initially synthesized and released by the cardiac ventricles in response to increased stretch and stress. This molecular precursor serves as the foundation for the active hormone B-type natriuretic peptide (BNP), which plays a central role in regulating cardiovascular homeostasis. When the heart faces pressure or volume overload, as seen in conditions like hypertrophic cardiomyopathy (HCM) or congestive heart failure (CHF), the production of proBNP escalates as an adaptive response. ProBNP acts as a physiological modulator, promoting vasodilation, sodium excretion, and diuresis to alleviate the cardiac workload and restore equilibrium within the cardiovascular system. As such, proBNP serves as a sentinel, finely tuned to cardiac hemodynamics and ready to signal any perturbations. Understanding the intricacies of proBNP synthesis, processing, and release is critical for comprehending feline cardiac health and diagnosing heart-related disorders with precision.



    About GDU


    GDU

    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.