Anti-MPV (A29) human monoclonal antibody (IgG1) for Therapeutics (positive control in vaccine development，benchmark in neutralizing antibodies discovery) and Diagnosis

Cat No.: GMP-MPV-Tg07-Ab001, GMP-MPV-Tg07-Ab002

The A33, L1, B5, and A25 genes encode the four proteins viz. A33, L1, B5, and A25, respectively. All of these immunogens are highly homologous (> 93%) between variola, monkeypox, and vaccinia. A33 is a type II integral membrane protein present as a dimer on the EV. Some evidence suggests A33 has a role in facilitating antibody-resistant cell-to-cell spread of orthopoxviruses. The A28 gene of vaccinia virus is conserved in all poxviruses and encodes a protein that is anchored to the surface of infectious intracellular mature virions (IMV) and consequently lies beneath the additional envelope of extracellular virions and required for the virus propagation. The product of the H3L gene, p35, is another envelope protein that is an immunodominant antigen found on orthopoxvirus. Strong immune responses to p35 protein have been detected in mice, sheep, rabbits, and humans. It has also been shown that the monoclonal antibodies against A28, A33, B5, L1 and H3 are cross protective cross-protective for variola, monkeypox, and vaccinia.

GeneMedi has quickly screened these neutralizing antibodies, which are valid for Monkeypox virus (MPV). They could be used as Benchmark Antibody, assist in neutralizing antibody discovery and development. They could also be used for Diagnosis. It should be noted that these antibodies have cross reactivity with vaccinia virus (VACV) and other Pox viruses.

Furthermore, the epitope of A29 has been designed specific for monkeypox virus. GeneMedi has quickly developed the antibody pair of MPV A29 to help accelerate the MPV diagnosis.



Order information

Catalog No. Package Price(In USD) Qty (Quantity) Sum(In USD)
GMP-MPV-Tg07-Ab001 1mg 3090
GMP-MPV-Tg07-Ab001 10mg 21890
GMP-MPV-Tg07-Ab001 100mg 148000
GMP-MPV-Tg07-Ab002 1mg 3090
GMP-MPV-Tg07-Ab002 10mg 21890
GMP-MPV-Tg07-Ab002 100mg 148000
GMP-MPV-Tg07-Ab001/Ab002 ≥100mg Inquiry
Shipping Cost: 760.00
Total:

For more than 100mg, click here for inquiry. >>


Description

Cat No. of Pruducts GMP-MPV-Tg07-Ab001, GMP-MPV-Tg07-Ab002
Product Name Anti-MPV (A29) human monoclonal antibody (IgG1)
Target A29
Expression platform Mammalian (human cell)
Isotypes Human IgG1
Bioactivity validation Validated in Monkeypox virus (MPV) A29 antigen protein binding affnity. ELISA validated as capture antibody and detection antibody. Pair recommendation with other A29 antibodies in A29 level test of Monkeypox virus (MPV) infectious diseases.
Tag hFc
Products description Anti-MPV (A29) human monoclonal antibody (IgG1) is a human IgG1 antibody produced by Mammalian (human cell). The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other A29 antibodies.
Reconized/Reactive Species Human
Purity Purity: ≥95% (SDS-PAGE)
Application ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.