Chlamydophila felis CF0218 antibody and antigen (recombinant protein)

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Diagnostic anti-Chlamydophila felis CF0218 antibodies pairs and antigen for animal health (animal Cat/Feline infectious disease inflammation of feline conjunctiva, rhinitis and respiratory problems) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P033-Tg001-Ag01	Recombinant Chlamydophila felis CF0218 protein	$3090.00
GMP-VT-P033-Tg001-Ab01	Anti-Chlamydophila felis CF0218 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P033-Tg001-Ab02	Anti-Chlamydophila felis CF0218 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P033-Tg001-Ab03	Anti-Chlamydophila felis CF0218 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P033-Tg001-Ab04	Anti-Chlamydophila felis CF0218 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P033-Tg001-Ag01
Product Name	Recombinant Chlamydophila felis CF0218 protein
Pathogen	Chlamydophila felis
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Chlamydophila felis CF0218 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Chlamydophila felis level test of animal Cat/Feline infectious disease with inflammation of feline conjunctiva, rhinitis and respiratory problems.
Tag	His
Product description	Recombinant Chlamydophila felis CF0218 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P033-Tg001-Ab01,GMP-VT-P033-Tg001-Ab02
Pathogen	Chlamydophila felis
Product Name	Anti-Chlamydophila felis CF0218 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Chlamydophila felis CF0218 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Chlamydophila felis antibodies in Chlamydophila felis level test of animal Cat/Feline infectious disease with inflammation of feline conjunctiva, rhinitis and respiratory problems.
Product description	Anti-Chlamydophila felis CF0218 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Chlamydophila felis antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P033-Tg001-Ab03,GMP-VT-P033-Tg001-Ab04
Pathogen	Chlamydophila felis
Product Name	Anti-Chlamydophila felis CF0218 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Chlamydophila felis CF0218 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Chlamydophila felis antibodies in Chlamydophila felis level test of animal Cat/Feline infectious disease with inflammation of feline conjunctiva, rhinitis and respiratory problems.
Product description	Anti-Chlamydophila felis CF0218 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Chlamydophila felis is a gram-negative, obligate intracellular bacterium belonging to the family Chlamydiaceae. It is a small, coccal-shaped organism with a diameter of approximately 0.2-1 micrometer. This pathogen has a unique biphasic developmental cycle, comprising two distinct forms, the elementary body (EB) and the reticulate body (RB).

The EB form, which is the infectious form of the pathogen, is adapted to extracellular survival and transmission. In contrast, the RB form, which is the replicative form, multiplies within the host cell in an intracellular environment. Chlamydophila felis is known to infect cats and is associated with respiratory diseases such as conjunctivitis, rhinitis, and pneumonia.

The pathogenicity of Chlamydophila felis is primarily attributed to its ability to evade host immune responses and its ability to establish persistent infections in the host. The MOMP protein plays a crucial role in the pathogenesis of this organism. It serves as the major antigen, inducing protective immune responses in the host and enabling bacteria to attach to and invade the host cells.

Chlamydophila felis infection is typically diagnosed using molecular methods, including PCR, real-time PCR, and DFA. PCR is a commonly used technique for the detection and identification of Chlamydiaceae family members, and various primers have been designed to target different regions of the bacterial genome. Real-time PCR is a more recent diagnostic technique that allows the quantification of bacterial DNA in a clinical sample. DFA involves detecting the presence of Chlamydophila felis by targeting the MOMP protein using fluorescent-labeled antibodies.

Several other methods are also available, including culturing the pathogen in cell culture or animal models, although these methods are less commonly used due to their lower sensitivity and longer turnaround times.

In terms of disease manifestation in cats, Chlamydophila felis infection can lead to conjunctivitis, which is characterized by inflammation of the eye's conjunctiva. Rhinitis, or inflammation of the nasal mucosa, can also occur, resulting in sneezing and nasal discharge. Pneumonia is another potential manifestation of Chlamydophila felis infection, which can result in breathing difficulties and coughing.

Infected cats may also experience decreased appetite, lethargy, and fever. In severe cases, particularly when left untreated, Chlamydophila felis infection can result in permanent damage to the lungs and eyes, leading to chronic respiratory and ocular diseases.

In summary, Chlamydophila felis is a pathogenic prokaryotic bacterium that infects cats, resulting in respiratory diseases such as conjunctivitis, rhinitis, and pneumonia. The pathogen's unique biphasic developmental cycle, comprising EB and RB forms, underlies its ability to survive within host cells and evade host immune responses. Molecular diagnostic methods such as PCR, real-time PCR, and DFA are used to identify Chlamydophila felis. Implementing these methods can enable early detection and appropriate management of infected cats, ultimately protecting both animal and public health.

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