Salmonella Abortusovis antibody and antigen (recombinant protein)

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Diagnostic anti-Salmonella Abortusovis antibodies pairs and antigen for animal health (animal Ovines/Sheep, Caprine/Goat infectious disease abortions and stillbirths in pregnant ewes and mortality in neonates) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P057-Tg001-Ag01	Recombinant Salmonella Abortusovis protein	$3090.00
GMP-VT-P057-Tg001-Ab01	Anti-Salmonella Abortusovis mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P057-Tg001-Ab02	Anti-Salmonella Abortusovis mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P057-Tg001-Ab03	Anti-Salmonella Abortusovis human monoclonal antibody (mAb)	$3090.00
GMP-VT-P057-Tg001-Ab04	Anti-Salmonella Abortusovis human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P057-Tg001-Ag01
Product Name	Recombinant Salmonella Abortusovis protein
Pathogen	Salmonella Abortusovis
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Salmonella Abortusovis antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Salmonella Abortusovis level test of animal Ovines/Sheep, Caprine/Goat infectious disease with abortions and stillbirths in pregnant ewes and mortality in neonates.
Tag	His
Product description	Recombinant Salmonella Abortusovis proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P057-Tg001-Ab01,GMP-VT-P057-Tg001-Ab02
Pathogen	Salmonella Abortusovis
Product Name	Anti-Salmonella Abortusovis mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Salmonella Abortusovis antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmonella Abortusovis antibodies in Salmonella Abortusovis level test of animal Ovines/Sheep, Caprine/Goat infectious disease with abortions and stillbirths in pregnant ewes and mortality in neonates.
Product description	Anti-Salmonella Abortusovis mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmonella Abortusovis antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P057-Tg001-Ab03,GMP-VT-P057-Tg001-Ab04
Pathogen	Salmonella Abortusovis
Product Name	Anti-Salmonella Abortusovis human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Salmonella Abortusovis antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmonella Abortusovis antibodies in Salmonella Abortusovis level test of animal Ovines/Sheep, Caprine/Goat infectious disease with abortions and stillbirths in pregnant ewes and mortality in neonates.
Product description	Anti-Salmonella Abortusovis mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Salmonella Abortusovis is a bacterial pathogen that primarily infects sheep, causing a disease called ovine brucellosis or enzootic abortion of ewes (EAE). This disease can have a significant impact on the sheep industry, leading to reduced viability and reproductive failure in affected animals.

Salmonella Abortusovis is a member of the Enterobacteriaceae family within the phylum Proteobacteria. These bacteria are gram-negative, facultative anaerobic, non-spore-forming rods shaped like short straight sticks, approximately 0.5-1.5 µm long and 0.2-0.5 µm wide. They are motile and possess peritrichous flagella, and they may also secrete fimbriae to adhere to host cells.

The surface of Salmonella Abortusovis is composed of various proteins, including O and H antigens, which play a crucial role in immune evasion and host invasion. The O antigen is a component of lipopolysaccharide (LPS), a complex molecule that covers the outer membrane of gram-negative bacteria. LPS is essential for maintaining the structural integrity of the bacterial cell wall and is recognized by host immune cells as a pathogen-associated molecular pattern (PAMP). The H antigen, on the other hand, is a protein flagellin that makes up the bacterial flagella, allowing the bacterium to move around and invade host cells more effectively.

Sheep are the primary host of Salmonella Abortusovis, but the pathogen can also infect other ruminant species such as goats and cattle. The disease caused by Salmonella Abortusovis in sheep, EAE, is characterized by reproductive failures such as abortions, stillbirths, and weak newborn lambs. The pathogen is usually transmitted from infected ewes to their fetuses or newborns via the placenta or milk. Infection can also occur through contaminated feed, water, or bedding materials.

The diagnosis of Salmonella Abortusovis infection in sheep can be challenging due to the similarity of its symptoms to other diseases such as chlamydiosis and toxoplasmosis. Serological tests such as the Rose Bengal plate agglutination test (RBPT), the complement fixation test (CFT), and the indirect enzyme-linked immunosorbent assay (iELISA) are commonly used to detect antibodies against Salmonella Abortusovis in sheep serum. Nucleic acid-based diagnostic methods such as polymerase chain reaction (PCR) and real-time PCR (qPCR) can detect DNA from Salmonella Abortusovis in various samples, including milk, blood, and fetal tissues. These diagnostic methods can target specific genes such as invA, which encodes an invasion protein, and ompA, which encodes an outer membrane protein.

In conclusion, Salmonella Abortusovis is a gram-negative, facultative anaerobic, non-spore-forming rod-shaped bacterium that primarily infects sheep, causing ovine brucellosis or EAE. The pathogen's surface proteins, O and H antigens, play a crucial role in immune evasion and host invasion. Diagnosis of Salmonella Abortusovis infection can be challenging due to the similarity of its symptoms to other diseases, but serological and nucleic acid-based diagnostic methods are available to detect the pathogen in various samples.

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