Caprine Arthritis Encephalitis Virus Capsid antibody and antigen (recombinant protein)

Diagnostic anti-Caprine Arthritis Encephalitis Virus Capsid antibodies pairs and antigen for animal health (animal Ovines/Sheep infectious disease Caprine arthritis encephalitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P058-Tg004-Ag01 Recombinant Caprine Arthritis Encephalitis Virus Capsid protein $3090.00
GMP-VT-P058-Tg004-Ab01 Anti-Caprine Arthritis Encephalitis Virus Capsid mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P058-Tg004-Ab02 Anti-Caprine Arthritis Encephalitis Virus Capsid mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P058-Tg004-Ab03 Anti-Caprine Arthritis Encephalitis Virus Capsid human monoclonal antibody (mAb) $3090.00
GMP-VT-P058-Tg004-Ab04 Anti-Caprine Arthritis Encephalitis Virus Capsid human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P058-Tg004-Ag01
Product Name Recombinant Caprine Arthritis Encephalitis Virus Capsid protein
Pathogen Caprine Arthritis Encephalitis Virus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Caprine Arthritis Encephalitis Virus Capsid antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Caprine Arthritis Encephalitis Virus level test of animal Ovines/Sheep infectious disease with Caprine arthritis encephalitis.
Tag His
Product description Recombinant Caprine Arthritis Encephalitis Virus Capsid proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P058-Tg004-Ab01,GMP-VT-P058-Tg004-Ab02
Pathogen Caprine Arthritis Encephalitis Virus
Product Name Anti-Caprine Arthritis Encephalitis Virus Capsid mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Caprine Arthritis Encephalitis Virus Capsid antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Caprine Arthritis Encephalitis Virus antibodies in Caprine Arthritis Encephalitis Virus level test of animal Ovines/Sheep infectious disease with Caprine arthritis encephalitis.
Product description Anti-Caprine Arthritis Encephalitis Virus Capsid mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Caprine Arthritis Encephalitis Virus antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P058-Tg004-Ab03,GMP-VT-P058-Tg004-Ab04
Pathogen Caprine Arthritis Encephalitis Virus
Product Name Anti-Caprine Arthritis Encephalitis Virus Capsid human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Caprine Arthritis Encephalitis Virus Capsid antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Caprine Arthritis Encephalitis Virus antibodies in Caprine Arthritis Encephalitis Virus level test of animal Ovines/Sheep infectious disease with Caprine arthritis encephalitis.
Product description Anti-Caprine Arthritis Encephalitis Virus Capsid mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen Information


    Caprine Arthritis Encephalitis Virus (CAEV) is a substantial concern for goat farmers worldwide as it is a lentivirus that primarily affects goats but can also infect sheep, llamas, and alpacas. The virus is transmitted by various routes such as milk, respiratory secretions, blood, and semen. CAEV infection can lead to chronic and debilitating diseases, including Caprine Arthritis Encephalitis (CAE), Caprine Arthritis and Pneumonia Syndrome (CAPS), and mastitis, which can cause significant damage to the farming industry due to decreased productivity and high treatment costs.

    CAEV is a type of Retroviridae virus that has a single-stranded RNA genome. This genome consists of several genes, including gag, pol, and env, which are common in retroviruses. Additionally, it also encodes several accessory proteins that are specific to lentiviruses, such as Tat, Rev, and Vif. The genome's gag gene encodes structural proteins, including matrix (MA), capsid (CA), and nucleocapsid (NC), important in virus assembly and budding. The pol gene codes for enzymes like reverse transcriptase, protease, and integrase, which play crucial roles in the replication of retroviruses. The third gene, env, encodes envelope glycoproteins that mediate viral entry into host cells and are essential for the pathogenicity of viruses.

    The CAEV virus primarily infects macrophages, dendritic cells, and monocytes, leading to the formation of inflammatory lesions in various organs, especially joints, brain, lungs, and mammary glands. Infected animals usually exhibit a long incubation period, with clinical signs becoming more apparent as they age. The most frequent symptoms of CAEV infection include joint stiffness, lameness, arthritis, ataxia, encephalitis, pneumonia, and mastitis.

    Various diagnostic methods are available for detecting CAEV infection in goats. Serological assays, such as enzyme-linked immunosorbent assay (ELISA), are used to detect the presence of specific antibodies against viral proteins in the animal's serum or milk. The ELISA test is usually more sensitive and specific than other diagnostic tests. Western blotting is also commonly used to identify viral proteins in serum samples. Another method is nucleic acid-based assays, such as polymerase chain reaction (PCR), southern blotting, and provirus amplification, which detect the presence of viral RNA or DNA in clinical samples. These methods typically target the gag or pol gene, and PCR has increased sensitivity over other testing techniques.

    Next-generation sequencing technology has enabled researchers to sequence and analyze the complete viral genome. This information is essential for molecular epidemiology studies, which aim to determine the origin and evolution of the virus. CAEV isolates from different geographical regions have shown significant genetic diversity, emphasizing the importance of molecular characterization for diagnostic purposes.

    In conclusion, CAEV is a significant concern for the agriculture industry worldwide. It is essential to prevent the spread of the virus by implementing control strategies such as testing, culling infected animals, and vaccination. By using diagnostic techniques, producers can identify infected animals early and take necessary precautions to reduce the impact on the farming industry. The continued research in molecular epidemiology and genomics will provide an in-depth understanding of the virus and enable the development of more effective vaccines and diagnostics.



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