Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen antibody and antigen (recombinant protein)

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Diagnostic anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease swine pleuropneumonia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P123-Tg001-Ag01	Recombinant Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen protein	$3090.00
GMP-VT-P123-Tg001-Ab01	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P123-Tg001-Ab02	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P123-Tg001-Ab03	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen human monoclonal antibody (mAb)	$3090.00
GMP-VT-P123-Tg001-Ab04	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen human monoclonal antibody (mAb)	$3090.00

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Product Description

Cat No.	GMP-VT-P123-Tg001-Ag01
Product Name	Recombinant Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen protein
Pathogen	Actinobacillus pleuropneumoniae serotype 2
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Actinobacillus pleuropneumoniae serotype 2 level test of animal Swine/Porcine/Pig infectious disease with swine pleuropneumonia.
Tag	His
Product description	Recombinant Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P123-Tg001-Ab01,GMP-VT-P123-Tg001-Ab02
Pathogen	Actinobacillus pleuropneumoniae serotype 2
Product Name	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Actinobacillus pleuropneumoniae serotype 2 antibodies in Actinobacillus pleuropneumoniae serotype 2 level test of animal Swine/Porcine/Pig infectious disease with swine pleuropneumonia.
Product description	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Actinobacillus pleuropneumoniae serotype 2 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P123-Tg001-Ab03,GMP-VT-P123-Tg001-Ab04
Pathogen	Actinobacillus pleuropneumoniae serotype 2
Product Name	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Actinobacillus pleuropneumoniae serotype 2 antibodies in Actinobacillus pleuropneumoniae serotype 2 level test of animal Swine/Porcine/Pig infectious disease with swine pleuropneumonia.
Product description	Anti-Actinobacillus pleuropneumoniae serotype 2 OMP (membrane protein) antigen mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Of the numerous pathogens that infect pigs, Actinobacillus pleuropneumoniae serotype 2 stands out as one of the most important bacterial pathogens responsible for causing porcine pleuropneumonia. Being a bacterium belonging to the family Pasteurellaceae, Actinobacillus pleuropneumoniae is characterized by its small, non-motile, and non-spore-forming rod-shaped cells. The pathogen measures between 0.5 and 2.0 micrometers in size.

The pathogenicity of Actinobacillus pleuropneumoniae involves several genes and proteins that contribute to the virulence and pathogenesis of the disease. One crucial gene is the Apx toxin gene, which encodes various virulence factors that help the bacteria evade the host immune system and cause disease. Other genes such as capsular polysaccharide genes and lipopolysaccharide genes contribute to bacterial adhesion and colonization on host tissues.

Actinobacillus pleuropneumoniae primarily affects pigs and is a highly contagious respiratory disease. The infection can be widespread through the herd and has severe economic repercussions for pig farmers worldwide. Clinical symptoms of the disease include fever, cough, nasal discharge, and difficulty breathing. In severe cases, pleurisy, lung abscess, and septicemia have also been reported, which may result in high morbidity and mortality rates.

Diagnostic methods for Actinobacillus pleuropneumoniae include bacterial culture, polymerase chain reaction (PCR), immunofluorescence assays, and enzyme-linked immunosorbent assays (ELISAs). Bacterial culture of Actinobacillus pleuropneumoniae can be difficult and requires special media and conditions. However, PCR testing has emerged as an alternative diagnostic method that offers high sensitivity and specificity. The most commonly targeted gene in PCR assays is the Apx toxin gene.

Immunofluorescence assays and ELISAs are serological diagnostic tools that detect antibodies against Actinobacillus pleuropneumoniae, indicating a previous infection. These assays measure antibody levels in serum samples and can differentiate between vaccinated animals and infected ones.

The control of Actinobacillus pleuropneumoniae infections involves the implementation of preventative strategies such as vaccination, biosecurity measures, and appropriate use of antibiotics. Vaccines targeting the Apx toxins have shown to provide protection against the pathogen, reducing the morbidity and mortality rates. However, the development of effective vaccines for all serotypes of Actinobacillus pleuropneumoniae remains a challenge.

In conclusion, Actinobacillus pleuropneumoniae serotype 2 is a significant bacterial pathogen affecting pig populations worldwide, leading to severe economic losses. Its pathogenicity is supported by crucial genes and proteins, including the Apx toxin gene responsible for encoding virulence factors. Diagnostic methods, including PCR, immunofluorescence assays, and ELISAs, play a crucial role in early detection, treatment, and prevention of the disease.

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