Infectious Bronchitis Virus - Variant QX antibody and antigen (recombinant protein)

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Diagnostic anti-Infectious Bronchitis Virus - Variant QX antibodies pairs and antigen for animal health (animal Chicken infectious disease Avian infectious bronchitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P161-Tg001-Ag01	Recombinant Infectious Bronchitis Virus - Variant QX protein	$3090.00
GMP-VT-P161-Tg001-Ab01	Anti-Infectious Bronchitis Virus - Variant QX mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P161-Tg001-Ab02	Anti-Infectious Bronchitis Virus - Variant QX mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P161-Tg001-Ab03	Anti-Infectious Bronchitis Virus - Variant QX human monoclonal antibody (mAb)	$3090.00
GMP-VT-P161-Tg001-Ab04	Anti-Infectious Bronchitis Virus - Variant QX human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P161-Tg001-Ag01
Product Name	Recombinant Infectious Bronchitis Virus - Variant QX protein
Pathogen	Infectious Bronchitis Virus - Variant QX
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Infectious Bronchitis Virus - Variant QX antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Infectious Bronchitis Virus - Variant QX level test of animal Chicken infectious disease with Avian infectious bronchitis.
Tag	His
Product description	Recombinant Infectious Bronchitis Virus - Variant QX proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P161-Tg001-Ab01,GMP-VT-P161-Tg001-Ab02
Pathogen	Infectious Bronchitis Virus - Variant QX
Product Name	Anti-Infectious Bronchitis Virus - Variant QX mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Infectious Bronchitis Virus - Variant QX antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant QX antibodies in Infectious Bronchitis Virus - Variant QX level test of animal Chicken infectious disease with Avian infectious bronchitis.
Product description	Anti-Infectious Bronchitis Virus - Variant QX mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant QX antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P161-Tg001-Ab03,GMP-VT-P161-Tg001-Ab04
Pathogen	Infectious Bronchitis Virus - Variant QX
Product Name	Anti-Infectious Bronchitis Virus - Variant QX human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Infectious Bronchitis Virus - Variant QX antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant QX antibodies in Infectious Bronchitis Virus - Variant QX level test of animal Chicken infectious disease with Avian infectious bronchitis.
Product description	Anti-Infectious Bronchitis Virus - Variant QX mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Infectious Bronchitis Virus (IBV) is an enveloped, positive-sense, single-stranded RNA virus belonging to the family Coronaviridae. It infects chickens, turkeys, and guinea fowl, causing respiratory signs such as coughing, sneezing, and nasal discharge, and in severe cases, leading to decreased egg production and quality. IBV is a significant concern for the poultry industry worldwide, as it causes substantial economic loss due to high morbidity and mortality rates.

IBV has several serotypes, including variant strains such as IBV-QX, which has emerged in recent years and is responsible for severe respiratory disease in broilers. Variant strains are characterized by their ability to mutate, change antigenicity, and infect new species, leading to significant challenges for diagnosis, control, and prevention.

The primary gene of IBV-QX, as mentioned earlier, is the S glycoprotein, which mediates viral attachment and entry into host cells. Several studies have shown that the S protein plays a critical role in viral pathogenesis and host range determination. The S protein is composed of two subunits, S1 and S2, with the former responsible for binding to receptors on host cells and the latter facilitating membrane fusion to enable viral entry.

Additionally, the N protein is essential in viral replication and assembly, while the E and M proteins are crucial for viral morphology and pathogenesis. A recent study showed that knockdown of the M protein could significantly reduce virus growth and virulence, highlighting its critical role in IBV pathogenesis.

Diagnosis of IBV-QX is critical for prompt control and prevention measures. Several diagnostic methods are used for IBV detection globally. These methods include virus isolation, serological testing, and molecular diagnostic methods such as RT-PCR. Of these methods, RT-PCR is becoming increasingly popular due to its high sensitivity and specificity. Several primers and probes have been developed for IBV detection, including primers targeting the N gene and the S1 subunit of the S protein. Furthermore, real-time RT-PCR assays have been developed for the fast and accurate detection of IBV.

Serological testing is another diagnostic method used widely in IBV detection. The most commonly used method is enzyme-linked immunosorbent assay (ELISA). ELISA kits are commercially available and widely used for serological surveillance and diagnosis of IBV infections. Other serological methods include virus neutralization tests and hemagglutination inhibition assays, which are used for epidemiological studies and vaccine monitoring.

In conclusion, IBV-QX is a significant threat to the poultry industry worldwide. The identification of novel variants and their control and prevention pose significant challenges for the industry. A detailed understanding of the virus's structure, pathogenesis, and diagnostic methods is crucial for developing effective control measures and preventing economic losses.

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