Infectious Bronchitis Virus - Variant Q1 antibody and antigen (recombinant protein)

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Diagnostic anti-Infectious Bronchitis Virus - Variant Q1 antibodies pairs and antigen for animal health (animal Chicken infectious disease Avian infectious bronchitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P162-Tg001-Ag01	Recombinant Infectious Bronchitis Virus - Variant Q1 protein	$3090.00
GMP-VT-P162-Tg001-Ab01	Anti-Infectious Bronchitis Virus - Variant Q1 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P162-Tg001-Ab02	Anti-Infectious Bronchitis Virus - Variant Q1 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P162-Tg001-Ab03	Anti-Infectious Bronchitis Virus - Variant Q1 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P162-Tg001-Ab04	Anti-Infectious Bronchitis Virus - Variant Q1 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P162-Tg001-Ag01
Product Name	Recombinant Infectious Bronchitis Virus - Variant Q1 protein
Pathogen	Infectious Bronchitis Virus - Variant Q1
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Infectious Bronchitis Virus - Variant Q1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Infectious Bronchitis Virus - Variant Q1 level test of animal Chicken infectious disease with Avian infectious bronchitis.
Tag	His
Product description	Recombinant Infectious Bronchitis Virus - Variant Q1 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P162-Tg001-Ab01,GMP-VT-P162-Tg001-Ab02
Pathogen	Infectious Bronchitis Virus - Variant Q1
Product Name	Anti-Infectious Bronchitis Virus - Variant Q1 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Infectious Bronchitis Virus - Variant Q1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant Q1 antibodies in Infectious Bronchitis Virus - Variant Q1 level test of animal Chicken infectious disease with Avian infectious bronchitis.
Product description	Anti-Infectious Bronchitis Virus - Variant Q1 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant Q1 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P162-Tg001-Ab03,GMP-VT-P162-Tg001-Ab04
Pathogen	Infectious Bronchitis Virus - Variant Q1
Product Name	Anti-Infectious Bronchitis Virus - Variant Q1 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Infectious Bronchitis Virus - Variant Q1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant Q1 antibodies in Infectious Bronchitis Virus - Variant Q1 level test of animal Chicken infectious disease with Avian infectious bronchitis.
Product description	Anti-Infectious Bronchitis Virus - Variant Q1 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

The Infectious Bronchitis Virus (IBV) is a coronavirus that primarily infects poultry species, particularly chickens. It is a highly infectious and contagious virus that spreads predominantly through aerosols and fomites such as feed, water systems, and equipment.

IBV Variant Q1 is a strain of IBV that was first identified in China in 1996. Unlike other strains of IBV, it affects the upper respiratory tract, resulting in severe respiratory disease in chickens. Poultry infected with IBV Variant Q1 typically exhibit clinical signs such as coughing, sneezing, nasal discharge, and rales. Additionally, it can cause kidney damage, leading to nephritis, which can result in significant economic losses for the poultry industry due to reduced egg production and mortality.

Genetically, IBV Variant Q1 has several unique characteristics that differentiate it from other strains of IBV. Phylogenetic analysis of its genome has revealed that it belongs to the Gammacoronavirus genus, which also includes other avian coronaviruses. The genome of IBV Variant Q1 is approximately 27.6 kilobases in size, and it encodes for at least nine open reading frames (ORFs) that produce several structural and nonstructural proteins.

Among the viral proteins encoded by IBV Variant Q1, the most studied is the spike (S) glycoprotein, which plays a critical role in host-cell entry. The S protein mediates the attachment of the virus to specific receptors on the host cell surface and induces membrane fusion to allow for viral entry. Additionally, it is a major immunogenic target of the host immune system, making it an attractive candidate for diagnostic and vaccine development.

Other viral proteins encoded by IBV Variant Q1 include the nucleocapsid (N) protein, which binds to the viral RNA to form a helical nucleocapsid structure, and the polymerase (P) protein, which is essential for viral replication. The P protein is responsible for generating an RNA-dependent RNA polymerase complex that copies the viral RNA genome into complementary RNA strands, allowing for viral RNA synthesis.

Several diagnostic methods have been developed to detect IBV Variant Q1 infections in poultry populations. RT-PCR and LAMP are nucleic acid-based tests that detect specific genes encoding viral proteins such as S protein, N protein, and P protein. These assays are highly sensitive and can detect even low levels of virus in samples. Additionally, serological assays detecting specific antibodies produced during infection with IBV Variant Q1 are used for diagnosis. These methods are useful for identifying infected birds, tracing outbreaks, and monitoring infection rates to help manage and control the spread of IBV Variant Q1 in poultry populations.

In conclusion, IBV Variant Q1 is a significant pathogen that causes severe respiratory and reproductive illnesses in chickens, resulting in significant economic losses to the poultry industry worldwide. It belongs to the Gammacoronavirus genus and has a unique genome encoding several viral proteins. Several diagnostic methods have been developed, including nucleic acid-based tests, which target genes encoding viral proteins, and serological assays for antibody detection. Improvements in the diagnosis, treatment, and prevention of IBV Variant Q1 infections are critical for controlling and minimizing the impact of this pathogen on the poultry industry.

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