Avian Influenza Virus Type A H5N1 subtype NP antibody and antigen (recombinant protein)

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Diagnostic anti-Avian Influenza Virus Type A H5N1 subtype NP antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Avian influenza) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P167-Tg001-Ag01	Recombinant Avian Influenza Virus Type A H5N1 subtype NP protein	$3090.00
GMP-VT-P167-Tg001-Ab01	Anti-Avian Influenza Virus Type A H5N1 subtype NP mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P167-Tg001-Ab02	Anti-Avian Influenza Virus Type A H5N1 subtype NP mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P167-Tg001-Ab03	Anti-Avian Influenza Virus Type A H5N1 subtype NP human monoclonal antibody (mAb)	$3090.00
GMP-VT-P167-Tg001-Ab04	Anti-Avian Influenza Virus Type A H5N1 subtype NP human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P167-Tg001-Ag01
Product Name	Recombinant Avian Influenza Virus Type A H5N1 subtype NP protein
Pathogen	Avian Influenza Virus Type A H5N1 subtype
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Avian Influenza Virus Type A H5N1 subtype NP antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian Influenza Virus Type A H5N1 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Tag	His
Product description	Recombinant Avian Influenza Virus Type A H5N1 subtype NP proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P167-Tg001-Ab01,GMP-VT-P167-Tg001-Ab02
Pathogen	Avian Influenza Virus Type A H5N1 subtype
Product Name	Anti-Avian Influenza Virus Type A H5N1 subtype NP mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Avian Influenza Virus Type A H5N1 subtype NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H5N1 subtype antibodies in Avian Influenza Virus Type A H5N1 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Product description	Anti-Avian Influenza Virus Type A H5N1 subtype NP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H5N1 subtype antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P167-Tg001-Ab03,GMP-VT-P167-Tg001-Ab04
Pathogen	Avian Influenza Virus Type A H5N1 subtype
Product Name	Anti-Avian Influenza Virus Type A H5N1 subtype NP human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Avian Influenza Virus Type A H5N1 subtype NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Influenza Virus Type A H5N1 subtype antibodies in Avian Influenza Virus Type A H5N1 subtype level test of animal Avian/Bird/Poultry infectious disease with Avian influenza.
Product description	Anti-Avian Influenza Virus Type A H5N1 subtype NP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Avian Influenza Virus Type A H5N1 subtype is a highly pathogenic virus that has the potential to cause severe respiratory illness in both animals and humans. The virus is commonly referred to as bird flu and has been found primarily in birds, specifically domestic poultry like chickens and ducks, as well as wild waterfowl such as geese and swans. However, it can infect a variety of other animals, including pigs, cats, and even tigers.

The virus belongs to the Orthomyxoviridae family, which are enveloped viruses with segmented, negative-sense RNA genomes. The virus is classified based on the presence of antigens on its surface, with H referring to hemagglutinin and N referring to neuraminidase. The H5N1 subtype has caused a significant number of outbreaks of avian influenza in domestic poultry, leading to significant economic losses for the agricultural industry and trade restrictions for affected countries.

The structure of Avian Influenza Virus Type A H5N1 subtype is essential for its function in replication and infection. The virus contains eight segments of single-stranded RNA, encoding at least 11 different proteins. The main genes responsible for the structure and function of the virus are HA and NA. HA is responsible for viral entry into host cells, binding to sialic acid receptors on the cell surface. NA is involved in viral release, cleaving sialic acid residues from the cell surface to facilitate viral spread and infection.

The virus primarily infects the respiratory system of its hosts, causing inflammation, edema, and necrosis of the respiratory tissues. In birds, the virus may cause mild to severe respiratory disease, including coughing, sneezing, and nasal discharge. In severe cases, the virus can cause acute respiratory distress syndrome, leading to high mortality rates within flocks. Infected birds may also exhibit digestive symptoms, including diarrhea, reduced feed intake, and decreased egg production.

In humans, Avian Influenza Virus Type A H5N1 subtype can cause severe respiratory infections, with symptoms similar to those of other influenza viruses but with a higher risk of developing severe complications such as pneumonia, acute respiratory distress syndrome, and even death. The virus is transmitted to humans through close contact with infected birds or contaminated surfaces, although rare cases of human-to-human transmission have been reported. However, the virus is not currently capable of sustained human-to-human transmission.

Various diagnostic methods have been developed for detecting Avian Influenza Virus Type A H5N1 subtype. Nucleic acid detection techniques like PCR and RT-PCR allow for the detection of viral RNA in clinical samples, with primers targeting specific regions of the viral genome like HA and NA. Serological tests can detect antibodies against the virus in blood samples, indicating prior infection or exposure. Rapid diagnostic tests utilizing lateral flow assays have also been developed for field use, allowing for quick and accurate detection of the virus in potentially affected animals or environments.

In conclusion, Avian Influenza Virus Type A H5N1 subtype is a highly pathogenic virus that poses a significant threat to both animal and human health. The virus primarily infects birds, causing severe respiratory disease with high mortality rates, as well as economic losses for the agricultural industry. In humans, the virus can cause severe respiratory infections with a high risk of complications and death, although human-to-human transmission is currently limited. Effective diagnostic methods are essential for the timely detection and control of outbreaks, as well as the development of effective preventive measures like vaccines.

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