Neospora caninum p38 antibody and antigen (recombinant protein)

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Diagnostic anti-Neospora caninum p38 antibodies pairs and antigen for animal health (animal Dog/Canine, Bovines/Cattle, Equine/Horse infectious disease Neosporosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P250-Tg001-Ag01	Recombinant Neospora caninum p38 protein	$3090.00
GMP-VT-P250-Tg001-Ab01	Anti-Neospora caninum p38 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P250-Tg001-Ab02	Anti-Neospora caninum p38 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P250-Tg001-Ab03	Anti-Neospora caninum p38 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P250-Tg001-Ab04	Anti-Neospora caninum p38 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P250-Tg001-Ag01
Product Name	Recombinant Neospora caninum p38 protein
Pathogen	Neospora caninum
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Neospora caninum p38 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Neospora caninum level test of animal Dog/Canine, Bovines/Cattle, Equine/Horse infectious disease with Neosporosis.
Tag	His
Product description	Recombinant Neospora caninum p38 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P250-Tg001-Ab01,GMP-VT-P250-Tg001-Ab02
Pathogen	Neospora caninum
Product Name	Anti-Neospora caninum p38 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Neospora caninum p38 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Neospora caninum antibodies in Neospora caninum level test of animal Dog/Canine, Bovines/Cattle, Equine/Horse infectious disease with Neosporosis.
Product description	Anti-Neospora caninum p38 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Neospora caninum antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P250-Tg001-Ab03,GMP-VT-P250-Tg001-Ab04
Pathogen	Neospora caninum
Product Name	Anti-Neospora caninum p38 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Neospora caninum p38 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Neospora caninum antibodies in Neospora caninum level test of animal Dog/Canine, Bovines/Cattle, Equine/Horse infectious disease with Neosporosis.
Product description	Anti-Neospora caninum p38 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Neospora caninum: Understanding a Protozoan Parasite

Neospora caninum, often referred to simply as Neospora, is a protozoan parasite of significant veterinary importance. In this comprehensive overview, we delve into the pathogen's taxonomy, structure, hosts, associated diseases, and diagnostic methods, shedding light on its complex biology and the critical need for management strategies.

Taxonomy and Classification:

Neospora caninum belongs to the kingdom Protista within the phylum Apicomplexa. This classification places it in the company of well-known parasitic organisms such as Toxoplasma gondii and Plasmodium spp., which cause diseases like toxoplasmosis and malaria, respectively. As a protozoan, Neospora caninum is eukaryotic, characterized by its single-celled structure and intracellular lifestyle.

Pathogen Structure and Key Molecules:

At the heart of Neospora caninum's infectious capabilities are its genes and proteins. The pathogen employs a range of molecular tools for host cell invasion and survival. Notable components include:

Surface Antigens: These genes and proteins are pivotal in recognizing and adhering to host cells, facilitating the initial stages of infection.

Rhoptry Proteins: Critical for the formation of the parasitophorous vacuole, a protective compartment within the host cell where the parasite resides.

Dense Granule Proteins: These molecules modulate host cell processes to create a suitable environment for Neospora's survival.

SAG1 (Surface Antigen 1): SAG1 is a well-studied protein used not only in diagnostic assays but also holds potential in the development of vaccines and targeted interventions.

Hosts and Associated Diseases:

Neospora caninum's life cycle involves two primary host categories - the definitive host (canids) and intermediate hosts (cattle and other livestock). In cattle, Neospora caninum infections can result in a condition known as neosporosis. This infectious disease is marked by adverse outcomes, including abortion, stillbirths, and neurological disorders in affected bovine neonates. The impact on the livestock industry can be economically significant due to reduced productivity and reproductive losses.

In the definitive host, typically dogs, Neospora caninum infections are often asymptomatic or exhibit mild clinical symptoms. However, these animals play a crucial role in the lifecycle of the parasite, shedding oocysts into the environment, which can infect intermediate hosts.

Diagnostic Methods:

Accurate diagnosis is paramount for the effective management of Neospora caninum infections. Several diagnostic methods are available:

Serological Tests: Enzyme-linked immunosorbent assays (ELISA) targeting specific Neospora antigens, such as SAG1, are used to detect antibodies in the blood or serum, indicating exposure or active infection.

Polymerase Chain Reaction (PCR): Nucleic acid-based assays, often targeting genes like Nc5 or ITS1, enable the detection of Neospora DNA in biological samples.

Immunohistochemistry: This technique helps identify the presence of Neospora antigens in tissue samples, aiding in the diagnosis of infections in affected animals.

Histopathology: Examination of tissue samples for characteristic Neospora-induced lesions, an important method, particularly in post-mortem examinations.

In conclusion, Neospora caninum, as a member of the Apicomplexa phylum, stands as a parasitic threat to livestock, with cattle being the primary intermediate host. The parasite's complex molecular structure and the availability of diagnostic methods targeting genes and proteins like SAG1 underline the need for research and biopharmaceutical developments to mitigate its impact on the agriculture industry and animal health. Further understanding of Neospora's biology opens the door to the potential development of effective management strategies and vaccines to reduce the economic losses associated with neosporosis.

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