Diagnostic anti-Borrelia burgdorferi sensu lato P100 antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease Borreliosis / Lyme disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Genemedi produces core animal health diagnostic ingredients-validated anti-Borrelia burgdorferi sensu lato P100 antibodies pairs and antigens for rapid test kit of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with Borreliosis / Lyme disease to evaluate the  animal health of Multiple species (Pet, Ruminants, Equine/Horse, Swine/Porcine/Pig).

The paired antibodies are both monoclonal antibodies (mab).

All the antibodies and antigens of  animal disease test are suitable for in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT. The antibody can act as a capture antibody and detection antibody. Antigens are validated as positive control materials.

Borreliosis, also known as Lyme disease, is caused by the bacterium Borrelia burgdorferi. Lyme borreliosis (LB) is a tick-transmitted bacterial infection caused by some members of the spirochete group Borrelia burgdorferi sensu lato. It is the most prevalent tick-transmitted infection in temperate areas of Europe, North America and Asia, and its geographic distribution is ever-increasing.

Borrelia burgdorferi sensu lato is a group of spirochete bacteria, which are prokaryotic cells with long, thin, spiral-shaped bodies. The genome of Borrelia burgdorferi sensu lato contains many genes and proteins, including outer surface proteins, flagellar proteins, and enzymes involved in metabolic pathways. Borrelia burgdorferi sensu lato primarily infects mammals, including humans, dogs, and horses, as well as some bird species. Diagnostic methods for Borrelia burgdorferi sensu lato include serological tests such as ELISA and Western blot, as well as nucleic acid-based tests such as PCR and real-time PCR. These methods detect specific genes or proteins of Borrelia burgdorferi sensu lato, such as the flagellin gene or the outer surface protein C (OspC). Detection of bacterial DNA or RNA in blood or tissue samples can confirm the presence of infectionThe major constituent of B. burgdorferi flagella is flagellin (41 kDa, p41). Whereas the lipoprotein OspC (22 kDa, p22) within the outer membrane of the spirochete induces an early antibody formation in the ECM phase of Lyme disease. The predominant immune responses to p41 and OspC are IgG mediated, even in early disease and it could be used as a marker for the diagnosis of Borrelia burgdorferi using Elisa.

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