beta-amyloid 40 (Aβ40) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-Aβ40-Ag01	Recombinant human APP/Aβ40/A4/AD1 Protein	3090
GMP-h-Aβ40-Ab01	Anti-human APP/Aβ40/A4/AD1 mouse monoclonal antibody (mAb)	1953
GMP-h-Aβ40-Ab02	Anti-human APP/Aβ40/A4/AD1 mouse monoclonal antibody (mAb)	1953
GMP-h-Aβ40-Ab03	Anti-human APP/Aβ40/A4/AD1 human monoclonal antibody (mAb)	1953
GMP-h-Aβ40-Ab04	Anti-human APP/Aβ40/A4/AD1 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-h-Aβ40-Ag01
Product Name	Recombinant human APP/Aβ40/A4/AD1 Protein
Target/Biomarker	beta-amyloid 40(Aβ40)
Alias of Target/Biomarker	AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	beta-amyloid 40 (Aβ40) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ40 level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD)) and related syndrome evaluation.
Products description	Recombinant human APP/Aβ40/A4/AD1 Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-Aβ40-Ab01, GMP-h-Aβ40-Ab02
Product Name	Anti-human APP/Aβ40/A4/AD1 mouse monoclonal antibody (mAb)
Target/Biomarker	beta-amyloid 40(Aβ40)
Alias of Target/Biomarker	AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human beta-amyloid 40 (Aβ40) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 40 (Aβ40) antibodies in Aβ40 level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD)) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human APP/Aβ40/A4/AD1 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-Aβ40-Ab03, GMP-h-Aβ40-Ab04
Product Name	Anti-human APP/Aβ40/A4/AD1 human monoclonal antibody (mAb)
Target/Biomarker	beta-amyloid 40(Aβ40)
Alias of Target/Biomarker	AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human beta-amyloid 40 (Aβ40) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 40 (Aβ40) antibodies in Aβ40 level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD)) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human APP/Aβ40/A4/AD1 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Figure 1. ELISA Validation of GeneMedi's Aβ40/Aβ42 antibody

Indirect ELISA analysis of clone [B], [A] and [A] antibody specificity, [B] and [A] can Recognizes Aβ40, while [A] has no cross-reactivity with Aβ40 Picture indirect ELISA analysis of cloned [B], [A] and [A] antibody specificity. [B] and [A] can recognize Aβ42 , while [A] has no cross-reaction with Aβ42.
A: GMP-h-Aβ42-Ab01
B: GMP-h-Aβ42-Ab02

The high-performance Aβ40 and Aβ42 antibody raw materials developed by GeneMedi have the advantages of good specificity and high sensitivity, and are the preferred raw materials for the development of in vitro diagnostics reagents for Alzheimer's disease.

Figure 2. CLIA verification data of GeneMedi's Aβ40/Aβ42 antibody

Beta-amyloid(1-42) antibodies (GMP-h-Aβ42-Ab02 and GMP-h-Aβ42-Ab01) established a standard curve by chemiluminescence method, and the detection range of Aβ42 was 100-1700 pg/mL.

Click to get more Data / Case study about the product.

Target/Biomarker information

Easily accessible biomarkers are needed for the early identification of individuals at risk of developing Alzheimer's disease (AD) in large population screening strategies. Low plasma Aβ42/40 was associated with more pronounced decline in cognitive function (measured by multiple outcomes) over time. Findings suggest that plasma Aβ42/40 may be used to identify people at risk of cognitive decline, being an alternative to more complex and expensive measures, such as positron emission tomography imaging or cerebrospinal fluid measurement.

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