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AAV2 variant (Y444F) Rep-Cap plasmid (retina-validated serotype AAV-RC plasmid)
GeneMedi's AAV2 variant (Y444F) Rep-Cap plasmid supplies the AAV2 Rep (replication) proteins and the AAV2 variant (Y444F) capsid protein.
You can produce AAV2 variant (Y444F) particle in 293T cell line in high titer using GeneMedi's AAV2 variant (Y444F) Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.
The tissue tropism of AAV2 variant (Y444F) vector has been validated in retina (retinal ganglion cells) by both intravitreal injection and sub-retinal injection., with potential applications in retina gene therapy.
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vector system
>>Product Description
| Cat.NO | Product Name | Organization Type | Price(In USD) | ||
|---|---|---|---|---|---|
| P-RC03 | AAV2 variant(Y444F) Rep-Cap Plasmid | Academic | 1719 | ||
| P-RC03 | AAV2 variant(Y444F) Rep-Cap Plasmid | Industry R&D (excluding CRO&CDMO&CXO) |
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| P-RC03 | AAV2 variant(Y444F) Rep-Cap Plasmid |
CRO&CDMO& CXO&CMC& Manufacturing company |
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| P-RC03-Kan | AAV2 variant(Y444F) Rep-Cap Plasmid(Kan resistance) |
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks. | |||||
| P-PK03 | AAV2 variant(Y444F) Vector
System
1. AAV2 variant (Y444F) Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug |
Academic | 3024 | ||
| P-PK03 | AAV2 variant(Y444F) Vector
System
1. AAV2 variant (Y444F) Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Industry R&D (excluding CRO&CDMO&CXO) |
|||
| P-PK03 | AAV2 variant(Y444F) Vector
System
1. AAV2 variant (Y444F) Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | CRO&CDMO& CXO&CMC& Manufacturing company |
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| P-PK03-Kan | AAV2 variant(Y444F) Vector
System(Kan resistance)
1. AAV2 variant (Y444F) Rep-Cap Plasmid(Kan resistance), 10mg 2. AAV Helper Plasmid(Kan resistance), 10mg 3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg |
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks. | |||||
| If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service. | |||||
|
Terms of sale: For Seed (5ug): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party. For plasmid production&lification (≥10mg): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party. |
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Citation
| Title | Publication | Date |
|---|---|---|
| Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain | CELL | 2018/6/14 |
| Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15 | Journal of Hepatology | 2023/5/20 |
| SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)–Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation | Circulation | 2020/3/24 |
| Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus | signal transduction and targeted therapy | 2022/2/18 |
| shear stress-induced cellular senescence blunts liver regeneration through Notch-Sirt1-P21/P16 axis | Hepatology | 2021/10/23 |
| [PDF] TIMP2 ameliorates blood–brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-Cadherin internalization | JOURNAL OF CLINICAL INVESTIGATION | 2023/11/28 |
| Epigenetic controls of Sonic hedgehog guarantee fidelity of epithelial adult stem cells trajectory in regeneration | Science Advances | 2022/7/22 |
| FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes | npj Regenerative Medicine | 2022/6/24 |
| KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function | Autophagy | 2023/9/15 |
| SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation | Journal of Experimental & Clinical Cancer Research | 2023/9/8 |
Validation data
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Associated products and services
| Products & Service | Products & Service Information |
|---|---|
| AAV Packaging service | Detail |
| Promise-ORF™ viral CDNA library | Detail |
| Plasmid DNA Rapid Preparation Service | Detail |
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