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AAV serotype 8 (AAV capsid 8) system - Introduction

GeneMedi's AAV8 Rep-Cap plasmid (serotype 8-specific AAV RC plasmid), also named AAV8-RC plasmid, or AAV-RC8 plasmid, is part of AAV8 packaging system. AAV8 Rep-Cap plamid supplies the AAV8 Rep (replication) proteins and the AAV8 capsid protein.

You can produce AAV8 paticle in 293T cell line in high titer using GeneMedi's AAV8 Rep-Cap plasmid with GeneMedi's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

The tissue tropism of AAV8 vector has been validated in retina, liver, pancreas and muscle, with potential applications in tissue-specific gene therapy.

Product Name Contents Price(In USD) Qty (Quantity) Sum(In USD)
AAV8 Rep-Cap Plasmid Serotype: AAV8
Size: 5ug
590
Shipping Cost: 360.00
Total:

AAV8 vector tissue tropism and gene transduction (serotype-specific AAV infection)

The tissue tropism of AAV8 vector has been validated in retina, liver, pancreas and muscle, with potential applications in tissue-specific gene therapy.

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Figure. Selected transduction results of AAV in vitro (in 293T cell line)

Virus and titer: AAV1/AAV6/AAV8/AAV-Rh10/AAV-DJ/AAV9-GFP, 1×1012 vg/ml
Cells: HEK-293T
MOI: MOI=1×104
Determine assay: 36 hours post infection, immunofluorescence microscopy


Other AAV Rep-Cap Plasmid


AAV1 Rep-Cap Plasmid

AAV2 Rep-Cap Plasmid

AAV2 variant (Y444F) Rep-Cap plasmid

AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plasmid

AAV2 variant (Y444F, Y730F, Y500F, Y272F, Y704F, Y252F) Rep-Cap plasmid

AAV2 variant(AAV2.7m8) Rep-Cap plasmid

AAV5 Rep-Cap Plasmid

AAV6 Rep-Cap Plasmid

AAV8-1m Rep-Cap plasmid

AAV8-2m Rep-Cap plasmid



AAV8 variant (Y733F, Y447F, Y275) Rep-Cap plasmid

AAV9 Rep-Cap Plasmid

AAV-Rh.10 Rep-Cap Plasmid

AAV-DJ Rep-Cap Plasmid

AAV-DJ/8 Rep-Cap Plasmid

AAV-Retro (Retrograde) Rep-Cap plasmid

AAV9-PHP.B Rep-Cap plasmid

AAV9-PHP.eB Rep-Cap plasmid

AAV9-PHP.S Rep-Cap plasmid