human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) receptor 10(CCR10) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) receptor 10 (CCR10) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. . Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28. This receptor is normally expressed by melanocytes, plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin, suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-MP0189-Ag-1chemokine (C-C motif) receptor 10 (CCR10) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP0189-Ab-1Anti-CCR10 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP0189-Ab-2Anti-CCR10 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP0189-Ag-1chemokine (C-C motif) receptor 10 (CCR10)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP0189-Ab-1Anti-CCR10 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP0189-Ab-2Anti-CCR10 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP0189-Ag-1chemokine (C-C motif) receptor 10 (CCR10)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP0189-Ab-1Anti-CCR10 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP0189-Ab-2Anti-CCR10 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP0189-Ag-1chemokine (C-C motif) receptor 10 (CCR10)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP0189-Ab-1Anti-CCR10 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP0189-Ab-2Anti-CCR10 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameCCR10
Full namechemokine (C-C motif) receptor 10
Gene ID2826
Gene NameCCR10
Gene AliasGPR2
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-MP0189-Ag-1, GM-Tg-rg-MP0189-Ag-1, GM-Tg-mg-MP0189-Ag-1, GM-Tg-cynog-MP0189-Ag-1
Products Namechemokine (C-C motif) receptor 10 (CCR10) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) receptor 10 (CCR10) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-MP0189-Ab-1, GM-Tg-hg-MP0189-Ab-2,
GM-Tg-rg-MP0189-Ab-1, GM-Tg-rg-MP0189-Ab-2,
GM-Tg-mg-MP0189-Ab-1, GM-Tg-mg-MP0189-Ab-2,
GM-Tg-cynog-MP0189-Ab-1, GM-Tg-cynog-MP0189-Ab-2
Products NameAnti-CCR10 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCR10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.