human, Cynomolgus/ Rhesus macaque, rat, mouse GDNF family receptor alpha 1(GFRA1) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse GDNF family receptor alpha 1 (GFRA1) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-MP0478-Ag-1GDNF family receptor alpha 1 (GFRA1) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP0478-Ab-1Anti-GFRA1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP0478-Ab-2Anti-GFRA1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP0478-Ag-1GDNF family receptor alpha 1 (GFRA1)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP0478-Ab-1Anti-GFRA1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP0478-Ab-2Anti-GFRA1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP0478-Ag-1GDNF family receptor alpha 1 (GFRA1)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP0478-Ab-1Anti-GFRA1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP0478-Ab-2Anti-GFRA1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP0478-Ag-1GDNF family receptor alpha 1 (GFRA1)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP0478-Ab-1Anti-GFRA1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP0478-Ab-2Anti-GFRA1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameGFRA1
Full nameGDNF family receptor alpha 1
Gene ID2674
Gene NameGFRA1
Gene AliasGDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-MP0478-Ag-1, GM-Tg-rg-MP0478-Ag-1, GM-Tg-mg-MP0478-Ag-1, GM-Tg-cynog-MP0478-Ag-1
Products NameGDNF family receptor alpha 1 (GFRA1) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse GDNF family receptor alpha 1 (GFRA1) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-MP0478-Ab-1, GM-Tg-hg-MP0478-Ab-2,
GM-Tg-rg-MP0478-Ab-1, GM-Tg-rg-MP0478-Ab-2,
GM-Tg-mg-MP0478-Ab-1, GM-Tg-mg-MP0478-Ab-2,
GM-Tg-cynog-MP0478-Ab-1, GM-Tg-cynog-MP0478-Ab-2
Products NameAnti-GFRA1 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GFRA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.