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human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 2 (Drosophila)(SPRY2) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to SPRY2/SPRY2 products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 2 (Drosophila) (SPRY2) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene.
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-MP1709-Ag-1 | sprouty homolog 2 (Drosophila) (SPRY2) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-MP1709-Ab-1 | Anti-SPRY2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-MP1709-Ab-2 | Anti-SPRY2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP1709-Ag-1 | sprouty homolog 2 (Drosophila) (SPRY2) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP1709-Ab-1 | Anti-SPRY2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP1709-Ab-2 | Anti-SPRY2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP1709-Ag-1 | sprouty homolog 2 (Drosophila) (SPRY2) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP1709-Ab-1 | Anti-SPRY2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP1709-Ab-2 | Anti-SPRY2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP1709-Ag-1 | sprouty homolog 2 (Drosophila) (SPRY2) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP1709-Ab-1 | Anti-SPRY2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP1709-Ab-2 | Anti-SPRY2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | SPRY2 |
| Full name | sprouty homolog 2 (Drosophila) |
| Gene ID | 10253 |
| Gene Name | SPRY2 |
| Gene Alias | IGAN3, hSPRY2 |
| Protein Sub-location | Transmembrane Protein |
Antigen Information
| Cat No. | GM-Tg-hg-MP1709-Ag-1, GM-Tg-rg-MP1709-Ag-1, GM-Tg-mg-MP1709-Ag-1, GM-Tg-cynog-MP1709-Ag-1 |
| Products Name | sprouty homolog 2 (Drosophila) (SPRY2) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 2 (Drosophila) (SPRY2) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-MP1709-Ab-1, GM-Tg-hg-MP1709-Ab-2, GM-Tg-rg-MP1709-Ab-1, GM-Tg-rg-MP1709-Ab-2, GM-Tg-mg-MP1709-Ab-1, GM-Tg-mg-MP1709-Ab-2, GM-Tg-cynog-MP1709-Ab-1, GM-Tg-cynog-MP1709-Ab-2 |
| Products Name | Anti-SPRY2 monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SPRY2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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