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human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 8(Tnfsf8) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to TNFSF8/TNFSF8 products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-MP1859-Ag-1 | tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-MP1859-Ab-1 | Anti-Tnfsf8 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-MP1859-Ab-2 | Anti-Tnfsf8 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP1859-Ag-1 | tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP1859-Ab-1 | Anti-Tnfsf8 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP1859-Ab-2 | Anti-Tnfsf8 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP1859-Ag-1 | tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP1859-Ab-1 | Anti-Tnfsf8 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP1859-Ab-2 | Anti-Tnfsf8 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP1859-Ag-1 | tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP1859-Ab-1 | Anti-Tnfsf8 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP1859-Ab-2 | Anti-Tnfsf8 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | Tnfsf8 |
| Full name | tumor necrosis factor (ligand) superfamily, member 8 |
| Gene ID | 944 |
| Gene Name | Tnfsf8 |
| Gene Alias | CD153, CD30L, CD30LG, TNLG3A |
| Protein Sub-location | Transmembrane Protein |
Antigen Information
| Cat No. | GM-Tg-hg-MP1859-Ag-1, GM-Tg-rg-MP1859-Ag-1, GM-Tg-mg-MP1859-Ag-1, GM-Tg-cynog-MP1859-Ag-1 |
| Products Name | tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-MP1859-Ab-1, GM-Tg-hg-MP1859-Ab-2, GM-Tg-rg-MP1859-Ab-1, GM-Tg-rg-MP1859-Ab-2, GM-Tg-mg-MP1859-Ab-1, GM-Tg-mg-MP1859-Ab-2, GM-Tg-cynog-MP1859-Ab-1, GM-Tg-cynog-MP1859-Ab-2 |
| Products Name | Anti-TNFSF8 monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFSF8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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