human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) ligand 8(CCL8) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) ligand 8 (CCL8) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.
CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.
CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1. In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes. CCL8 is also involved in attracting macrophages to the decidua in labor.
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Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
GM-Tg-hg-SE0751-Ag-1 | chemokine (C-C motif) ligand 8 (CCL8) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-SE0751-Ab-1 | Anti-CCL8 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-SE0751-Ab-2 | Anti-CCL8 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-SE0751-Ag-1 | chemokine (C-C motif) ligand 8 (CCL8) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-SE0751-Ab-1 | Anti-CCL8 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-SE0751-Ab-2 | Anti-CCL8 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-SE0751-Ag-1 | chemokine (C-C motif) ligand 8 (CCL8) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-SE0751-Ab-1 | Anti-CCL8 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-SE0751-Ab-2 | Anti-CCL8 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-SE0751-Ag-1 | chemokine (C-C motif) ligand 8 (CCL8) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-SE0751-Ab-1 | Anti-CCL8 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-SE0751-Ab-2 | Anti-CCL8 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Target Information
Target Name | CCL8 |
Full name | chemokine (C-C motif) ligand 8 |
Gene ID | 6355 |
Gene Name | CCL8 |
Gene Alias | HC14, MCP-2, MCP2, SCYA10, SCYA8 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Antigen Information
Cat No. | GM-Tg-hg-SE0751-Ag-1, GM-Tg-rg-SE0751-Ag-1, GM-Tg-mg-SE0751-Ag-1, GM-Tg-cynog-SE0751-Ag-1 |
Products Name | chemokine (C-C motif) ligand 8 (CCL8) protein |
Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
Tag | His |
Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) ligand 8 (CCL8) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
Catalog No. | GM-Tg-hg-SE0751-Ab-1, GM-Tg-hg-SE0751-Ab-2, GM-Tg-rg-SE0751-Ab-1, GM-Tg-rg-SE0751-Ab-2, GM-Tg-mg-SE0751-Ab-1, GM-Tg-mg-SE0751-Ab-2, GM-Tg-cynog-SE0751-Ab-1, GM-Tg-cynog-SE0751-Ab-2 |
Products Name | Anti-CCL8 monoclonal antibody |
Format | mab |
Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
Derivation (species) | Mouse |
Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CCL8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |