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human, Cynomolgus/ Rhesus macaque, rat, mouse cartilage intermediate layer protein, nucleotide pyrophosphohydrolase(CILP) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to CILP/CILP products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-SE0779-Ag-1 | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-SE0779-Ab-1 | Anti-CILP monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-SE0779-Ab-2 | Anti-CILP monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-SE0779-Ag-1 | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-SE0779-Ab-1 | Anti-CILP monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-SE0779-Ab-2 | Anti-CILP monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-SE0779-Ag-1 | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-SE0779-Ab-1 | Anti-CILP monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-SE0779-Ab-2 | Anti-CILP monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-SE0779-Ag-1 | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-SE0779-Ab-1 | Anti-CILP monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-SE0779-Ab-2 | Anti-CILP monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | CILP |
| Full name | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase |
| Gene ID | 8483 |
| Gene Name | CILP |
| Gene Alias | CILP-1, HsT18872 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
Antigen Information
| Cat No. | GM-Tg-hg-SE0779-Ag-1, GM-Tg-rg-SE0779-Ag-1, GM-Tg-mg-SE0779-Ag-1, GM-Tg-cynog-SE0779-Ag-1 |
| Products Name | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-SE0779-Ab-1, GM-Tg-hg-SE0779-Ab-2, GM-Tg-rg-SE0779-Ab-1, GM-Tg-rg-SE0779-Ab-2, GM-Tg-mg-SE0779-Ab-1, GM-Tg-mg-SE0779-Ab-2, GM-Tg-cynog-SE0779-Ab-1, GM-Tg-cynog-SE0779-Ab-2 |
| Products Name | Anti-CILP monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CILP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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