human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 6(GDF6) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 6 (GDF6) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Growth differentiation factor 6 (GDF6) is a protein that in humans is encoded by the GDF6 gene. GDF6 belongs to the transforming growth factor beta superfamily and may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins, and control eye development. Growth differentiation factor 6 (GDF6) is a regulatory protein associated with growth and differentiation of developing embryos. GDF6 is encoded by the GDF6 gene. It is a member the transforming growth factor beta superfamily which is a group of proteins involved in early regulation of cell growth and development. GDF6 has been shown to play an important role in the patterning of the epidermis and bone and joint formation. GDF6 induces genes related to the development of the epidermis and can bind directly to noggin, a gene that controls neural development, to block its effect. GDF6 interacts with bone morphogenetic proteins (BMPs) to form heterodimers that may work to regulate neural induction and patterning in developing embryos. By developing a GDF6 “knockout” model, scientists repressed expression of GDF6 in developing mice embryos. Through this experiment, the scientists were able to directly link GDF6 with several skull and vertebral joint disorders, such as scoliosis and chondrodysplasia, Grebe type.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-SE0941-Ag-1growth differentiation factor 6 (GDF6) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-SE0941-Ab-1Anti-GDF6 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-SE0941-Ab-2Anti-GDF6 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-SE0941-Ag-1growth differentiation factor 6 (GDF6)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-SE0941-Ab-1Anti-GDF6 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-SE0941-Ab-2Anti-GDF6 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-SE0941-Ag-1growth differentiation factor 6 (GDF6)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-SE0941-Ab-1Anti-GDF6 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-SE0941-Ab-2Anti-GDF6 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-SE0941-Ag-1growth differentiation factor 6 (GDF6)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-SE0941-Ab-1Anti-GDF6 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-SE0941-Ab-2Anti-GDF6 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameGDF6
Full namegrowth differentiation factor 6
Gene ID392255
Gene NameGDF6
Gene AliasBMP-13, BMP13, CDMP2, KFM, KFS, KFS1, KFSL, SGM1, SYNS4
Protein Sub-locationSecreted Protein/Potential Cytokines

Antigen Information

Cat No.GM-Tg-hg-SE0941-Ag-1, GM-Tg-rg-SE0941-Ag-1, GM-Tg-mg-SE0941-Ag-1, GM-Tg-cynog-SE0941-Ag-1
Products Namegrowth differentiation factor 6 (GDF6) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 6 (GDF6) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-SE0941-Ab-1, GM-Tg-hg-SE0941-Ab-2,
GM-Tg-rg-SE0941-Ab-1, GM-Tg-rg-SE0941-Ab-2,
GM-Tg-mg-SE0941-Ab-1, GM-Tg-mg-SE0941-Ab-2,
GM-Tg-cynog-SE0941-Ab-1, GM-Tg-cynog-SE0941-Ab-2
Products NameAnti-GDF6 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GDF6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.