human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) receptor 4(CCR4) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) receptor 4 (CCR4) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194). The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2 (MCP-1) CCL4 (MIP-1) CCL5 (RANTES) CCL17 (TARC) CCL22 (Macrophage-derived chemokine) Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. CCR4 and CAF-1 form a deadenylase complex. The complex cooperates with the release factor eRF3 and PABPC1 to shorten the poly(A) tail of mRNA during translation.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T06955-Ag-1chemokine (C-C motif) receptor 4 (CCR4) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T06955-Ab-1Anti-CCR4 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T06955-Ab-2Anti-CCR4 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T06955-Ag-1chemokine (C-C motif) receptor 4 (CCR4)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T06955-Ab-1Anti-CCR4 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T06955-Ab-2Anti-CCR4 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T06955-Ag-1chemokine (C-C motif) receptor 4 (CCR4)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T06955-Ab-1Anti-CCR4 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T06955-Ab-2Anti-CCR4 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T06955-Ag-1chemokine (C-C motif) receptor 4 (CCR4)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T06955-Ab-1Anti-CCR4 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T06955-Ab-2Anti-CCR4 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameCCR4
Full namechemokine (C-C motif) receptor 4
Gene ID1233
Gene NameCCR4
Gene AliasCC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T06955-Ag-1, GM-Tg-rg-T06955-Ag-1, GM-Tg-mg-T06955-Ag-1, GM-Tg-cynog-T06955-Ag-1
Products Namechemokine (C-C motif) receptor 4 (CCR4) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) receptor 4 (CCR4) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T06955-Ab-1, GM-Tg-hg-T06955-Ab-2,
GM-Tg-rg-T06955-Ab-1, GM-Tg-rg-T06955-Ab-2,
GM-Tg-mg-T06955-Ab-1, GM-Tg-mg-T06955-Ab-2,
GM-Tg-cynog-T06955-Ab-1, GM-Tg-cynog-T06955-Ab-2
Products NameAnti-CCR4 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCR4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.