human, Cynomolgus/ Rhesus macaque, rat, mouse activin A receptor, type I(ACVR1) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse activin A receptor, type I (ACVR1) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin receptor-like kinase-2). ACVR1 has been linked to the 2q23-24 region of the genome. This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. While knock-out models with this gene are in progress, the ACVR1 gene has been connected to fibrodysplasia ossificans progressiva, a disease characterized by the formation of heterotopic bone throughout the body. It is a bone morphogenetic protein receptor, type 1.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T12091-Ag-1activin A receptor, type I (ACVR1) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T12091-Ab-1Anti-ACVR1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T12091-Ab-2Anti-ACVR1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T12091-Ag-1activin A receptor, type I (ACVR1)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T12091-Ab-1Anti-ACVR1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T12091-Ab-2Anti-ACVR1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T12091-Ag-1activin A receptor, type I (ACVR1)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T12091-Ab-1Anti-ACVR1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T12091-Ab-2Anti-ACVR1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T12091-Ag-1activin A receptor, type I (ACVR1)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T12091-Ab-1Anti-ACVR1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T12091-Ab-2Anti-ACVR1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameACVR1
Full nameactivin A receptor, type I
Gene ID90
Gene NameACVR1
Gene AliasACTRIA, ACVRLK2, ALK2, FOP, SKR1, TSRI, ACVR1
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T12091-Ag-1, GM-Tg-rg-T12091-Ag-1, GM-Tg-mg-T12091-Ag-1, GM-Tg-cynog-T12091-Ag-1
Products Nameactivin A receptor, type I (ACVR1) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse activin A receptor, type I (ACVR1) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T12091-Ab-1, GM-Tg-hg-T12091-Ab-2,
GM-Tg-rg-T12091-Ab-1, GM-Tg-rg-T12091-Ab-2,
GM-Tg-mg-T12091-Ab-1, GM-Tg-mg-T12091-Ab-2,
GM-Tg-cynog-T12091-Ab-1, GM-Tg-cynog-T12091-Ab-2
Products NameAnti-ALK-2/ACVR1 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ALK-2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.