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human, Cynomolgus/ Rhesus macaque, rat, mouse leukemia inhibitory factor(LIF) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to LIF/LIF products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse leukemia inhibitory factor (LIF) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.
LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. p53 regulated LIF has been shown to facilitate implantation in the mouse model and possibly in humans. It has been suggested that recombinant human LIF might help to improve the implantation rate in women with unexplained infertility.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-T29774-Ag-1 | leukemia inhibitory factor (LIF) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T29774-Ab-1 | Anti-LIF monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T29774-Ab-2 | Anti-LIF monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T29774-Ag-1 | leukemia inhibitory factor (LIF) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T29774-Ab-1 | Anti-LIF monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T29774-Ab-2 | Anti-LIF monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T29774-Ag-1 | leukemia inhibitory factor (LIF) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T29774-Ab-1 | Anti-LIF monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T29774-Ab-2 | Anti-LIF monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T29774-Ag-1 | leukemia inhibitory factor (LIF) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T29774-Ab-1 | Anti-LIF monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T29774-Ab-2 | Anti-LIF monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | LIF |
| Full name | leukemia inhibitory factor |
| Gene ID | 3976 |
| Gene Name | LIF |
| Gene Alias | CDF, DIA, HILDA, MLPLI |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
Antigen Information
| Cat No. | GM-Tg-hg-T29774-Ag-1, GM-Tg-rg-T29774-Ag-1, GM-Tg-mg-T29774-Ag-1, GM-Tg-cynog-T29774-Ag-1 |
| Products Name | leukemia inhibitory factor (LIF) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse leukemia inhibitory factor (LIF) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-T29774-Ab-1, GM-Tg-hg-T29774-Ab-2, GM-Tg-rg-T29774-Ab-1, GM-Tg-rg-T29774-Ab-2, GM-Tg-mg-T29774-Ab-1, GM-Tg-mg-T29774-Ab-2, GM-Tg-cynog-T29774-Ab-1, GM-Tg-cynog-T29774-Ab-2 |
| Products Name | Anti-LIF monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LIF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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