human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 15(GDF15) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 15 (GDF15) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Growth/differentiation factor 15 (GDF15) was first identified as Macrophage inhibitory cytokine-1 or MIC-1. It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions, GDF-15 is expressed in low concentrations in most organs and upregulated because of injury of organs such as liver, kidney, heart and lung. The function of GDF-15 is not fully clear but it seems to have a role in regulating inflammatory pathways and to be involved in regulating apoptosis, cell repair and cell growth, which are biological processes observed in cardiovascular and neoplastic disorders. GDF-15 has shown to be a strong prognostic protein in patients with different diseases such as heart diseases and cancer. Metformin was shown to cause increased levels of GDF-15. This increase mediates the effect of body weight loss by metformin. A monoclonal antibody (mAB1) that neutralizes circulating GDF-15 is being tested in mice and non-human primates as a potential treatment for cancer-related cachexia.

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