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human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 15(GDF15) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to GDF15/GDF15 products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 15 (GDF15) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Growth/differentiation factor 15 (GDF15) was first identified as Macrophage inhibitory cytokine-1 or MIC-1.
It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions, GDF-15 is expressed in low concentrations in most organs and upregulated because of injury of organs such as liver, kidney, heart and lung.
The function of GDF-15 is not fully clear but it seems to have a role in regulating inflammatory pathways and to be involved in regulating apoptosis, cell repair and cell growth, which are biological processes observed in cardiovascular and neoplastic disorders. GDF-15 has shown to be a strong prognostic protein in patients with different diseases such as heart diseases and cancer.
Metformin was shown to cause increased levels of GDF-15. This increase mediates the effect of body weight loss by metformin.
A monoclonal antibody (mAB1) that neutralizes circulating GDF-15 is being tested in mice and non-human primates as a potential treatment for cancer-related cachexia.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-T33245-Ag-1 | growth differentiation factor 15 (GDF15) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T33245-Ab-1 | Anti-GDF15 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T33245-Ab-2 | Anti-GDF15 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T33245-Ag-1 | growth differentiation factor 15 (GDF15) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T33245-Ab-1 | Anti-GDF15 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T33245-Ab-2 | Anti-GDF15 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T33245-Ag-1 | growth differentiation factor 15 (GDF15) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T33245-Ab-1 | Anti-GDF15 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T33245-Ab-2 | Anti-GDF15 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T33245-Ag-1 | growth differentiation factor 15 (GDF15) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T33245-Ab-1 | Anti-GDF15 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T33245-Ab-2 | Anti-GDF15 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | GDF15 |
| Full name | growth differentiation factor 15 |
| Gene ID | 9518 |
| Gene Name | GDF15 |
| Gene Alias | GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
Antigen Information
| Cat No. | GM-Tg-hg-T33245-Ag-1, GM-Tg-rg-T33245-Ag-1, GM-Tg-mg-T33245-Ag-1, GM-Tg-cynog-T33245-Ag-1 |
| Products Name | growth differentiation factor 15 (GDF15) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse growth differentiation factor 15 (GDF15) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-T33245-Ab-1, GM-Tg-hg-T33245-Ab-2, GM-Tg-rg-T33245-Ab-1, GM-Tg-rg-T33245-Ab-2, GM-Tg-mg-T33245-Ab-1, GM-Tg-mg-T33245-Ab-2, GM-Tg-cynog-T33245-Ab-1, GM-Tg-cynog-T33245-Ab-2 |
| Products Name | Anti-GDF15 monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GDF15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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