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human, Cynomolgus/ Rhesus macaque, rat, mouse notch 3(NOTCH3) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to NOTCH3/NOTCH3 products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse notch 3 (NOTCH3) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene.
This gene encodes the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-T44684-Ag-1 | notch 3 (NOTCH3) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T44684-Ab-1 | Anti-NOTCH3 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T44684-Ab-2 | Anti-NOTCH3 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T44684-Ag-1 | notch 3 (NOTCH3) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T44684-Ab-1 | Anti-NOTCH3 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T44684-Ab-2 | Anti-NOTCH3 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T44684-Ag-1 | notch 3 (NOTCH3) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T44684-Ab-1 | Anti-NOTCH3 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T44684-Ab-2 | Anti-NOTCH3 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T44684-Ag-1 | notch 3 (NOTCH3) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T44684-Ab-1 | Anti-NOTCH3 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T44684-Ab-2 | Anti-NOTCH3 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | NOTCH3 |
| Full name | notch 3 |
| Gene ID | 4854 |
| Gene Name | NOTCH3 |
| Gene Alias | CADASIL, CADASIL1, CASIL, IMF2, LMNS |
| Protein Sub-location | Transmembrane Protein |
Antigen Information
| Cat No. | GM-Tg-hg-T44684-Ag-1, GM-Tg-rg-T44684-Ag-1, GM-Tg-mg-T44684-Ag-1, GM-Tg-cynog-T44684-Ag-1 |
| Products Name | notch 3 (NOTCH3) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse notch 3 (NOTCH3) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-T44684-Ab-1, GM-Tg-hg-T44684-Ab-2, GM-Tg-rg-T44684-Ab-1, GM-Tg-rg-T44684-Ab-2, GM-Tg-mg-T44684-Ab-1, GM-Tg-mg-T44684-Ab-2, GM-Tg-cynog-T44684-Ab-1, GM-Tg-cynog-T44684-Ab-2 |
| Products Name | Anti-NOTCH3 monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NOTCH3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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