human, Cynomolgus/ Rhesus macaque, rat, mouse notch 3(NOTCH3) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse notch 3 (NOTCH3) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene. This gene encodes the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T44684-Ag-1notch 3 (NOTCH3) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T44684-Ab-1Anti-NOTCH3 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T44684-Ab-2Anti-NOTCH3 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T44684-Ag-1notch 3 (NOTCH3)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T44684-Ab-1Anti-NOTCH3 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T44684-Ab-2Anti-NOTCH3 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T44684-Ag-1notch 3 (NOTCH3)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T44684-Ab-1Anti-NOTCH3 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T44684-Ab-2Anti-NOTCH3 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T44684-Ag-1notch 3 (NOTCH3)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T44684-Ab-1Anti-NOTCH3 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T44684-Ab-2Anti-NOTCH3 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameNOTCH3
Full namenotch 3
Gene ID4854
Gene NameNOTCH3
Gene AliasCADASIL, CADASIL1, CASIL, IMF2, LMNS
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T44684-Ag-1, GM-Tg-rg-T44684-Ag-1, GM-Tg-mg-T44684-Ag-1, GM-Tg-cynog-T44684-Ag-1
Products Namenotch 3 (NOTCH3) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse notch 3 (NOTCH3) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T44684-Ab-1, GM-Tg-hg-T44684-Ab-2,
GM-Tg-rg-T44684-Ab-1, GM-Tg-rg-T44684-Ab-2,
GM-Tg-mg-T44684-Ab-1, GM-Tg-mg-T44684-Ab-2,
GM-Tg-cynog-T44684-Ab-1, GM-Tg-cynog-T44684-Ab-2
Products NameAnti-NOTCH3 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NOTCH3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.