human, Cynomolgus/ Rhesus macaque, rat, mouse transforming growth factor, beta receptor 1(TGFBR1) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse transforming growth factor, beta receptor 1 (TGFBR1) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family for the TGF beta superfamily of signaling ligands. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transducing the TGF-β signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys–Dietz aortic aneurysm syndrome (LDS, LDAS).


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T53389-Ag-1transforming growth factor, beta receptor 1 (TGFBR1) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T53389-Ab-1Anti-TGFBR1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T53389-Ab-2Anti-TGFBR1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T53389-Ag-1transforming growth factor, beta receptor 1 (TGFBR1)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T53389-Ab-1Anti-TGFBR1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T53389-Ab-2Anti-TGFBR1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T53389-Ag-1transforming growth factor, beta receptor 1 (TGFBR1)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T53389-Ab-1Anti-TGFBR1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T53389-Ab-2Anti-TGFBR1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T53389-Ag-1transforming growth factor, beta receptor 1 (TGFBR1)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T53389-Ab-1Anti-TGFBR1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T53389-Ab-2Anti-TGFBR1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameTGFBR1
Full nametransforming growth factor, beta receptor 1
Gene ID7046
Gene NameTGFBR1
Gene AliasAAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TBR-i, TBRI, TGFR-1, tbetaR-I
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T53389-Ag-1, GM-Tg-rg-T53389-Ag-1, GM-Tg-mg-T53389-Ag-1, GM-Tg-cynog-T53389-Ag-1
Products Nametransforming growth factor, beta receptor 1 (TGFBR1) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse transforming growth factor, beta receptor 1 (TGFBR1) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T53389-Ab-1, GM-Tg-hg-T53389-Ab-2,
GM-Tg-rg-T53389-Ab-1, GM-Tg-rg-T53389-Ab-2,
GM-Tg-mg-T53389-Ab-1, GM-Tg-mg-T53389-Ab-2,
GM-Tg-cynog-T53389-Ab-1, GM-Tg-cynog-T53389-Ab-2
Products NameAnti-TGFBR1 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TGFBR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.