human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor, alpha-induced protein 3(TNFAIP3) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and a deubiquitinating enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The A20 protein is ancient, and protein homolog can be found as far back as cnidaria (corals, jellyfish, anemones) with a conserved protein domain composition. Using knockout mouse models of TNFAIP3 and its transcriptional repressor (i.e. KCHIP3), TNFAIP3 has been shown to be critical for limiting inflammation by terminating endotoxin- and TNF-induced NF-kappa B responses. In brief, deubiquitinase function of TNFAIP3 was shown to remove ubiquitin chains from VE-cadherin to prevent loss of VE-cadherin at the endothelial adherens junctions.
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Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
GM-Tg-hg-T56474-Ag-1 | tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-T56474-Ab-1 | Anti-TNFAIP3 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-T56474-Ab-2 | Anti-TNFAIP3 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T56474-Ag-1 | tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T56474-Ab-1 | Anti-TNFAIP3 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T56474-Ab-2 | Anti-TNFAIP3 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T56474-Ag-1 | tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T56474-Ab-1 | Anti-TNFAIP3 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T56474-Ab-2 | Anti-TNFAIP3 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T56474-Ag-1 | tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T56474-Ab-1 | Anti-TNFAIP3 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T56474-Ab-2 | Anti-TNFAIP3 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Target Information
Target Name | TNFAIP3 |
Full name | tumor necrosis factor, alpha-induced protein 3 |
Gene ID | 7128 |
Gene Name | TNFAIP3 |
Gene Alias | A20, AISBL, OTUD7C, TNFA1P2 |
Protein Sub-location | Introcelluar Protein |
Antigen Information
Cat No. | GM-Tg-hg-T56474-Ag-1, GM-Tg-rg-T56474-Ag-1, GM-Tg-mg-T56474-Ag-1, GM-Tg-cynog-T56474-Ag-1 |
Products Name | tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) protein |
Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
Tag | His |
Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
Catalog No. | GM-Tg-hg-T56474-Ab-1, GM-Tg-hg-T56474-Ab-2, GM-Tg-rg-T56474-Ab-1, GM-Tg-rg-T56474-Ab-2, GM-Tg-mg-T56474-Ab-1, GM-Tg-mg-T56474-Ab-2, GM-Tg-cynog-T56474-Ab-1, GM-Tg-cynog-T56474-Ab-2 |
Products Name | Anti-TNFAIP3 monoclonal antibody |
Format | mab |
Category of antibody | Therapeutics Target antibody, Cytokine antibody |
Derivation (species) | Mouse |
Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-TNFAIP3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |