human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor, alpha-induced protein 3(TNFAIP3) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene. This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and a deubiquitinating enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The A20 protein is ancient, and protein homolog can be found as far back as cnidaria (corals, jellyfish, anemones) with a conserved protein domain composition. Using knockout mouse models of TNFAIP3 and its transcriptional repressor (i.e. KCHIP3), TNFAIP3 has been shown to be critical for limiting inflammation by terminating endotoxin- and TNF-induced NF-kappa B responses. In brief, deubiquitinase function of TNFAIP3 was shown to remove ubiquitin chains from VE-cadherin to prevent loss of VE-cadherin at the endothelial adherens junctions.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T56474-Ag-1tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T56474-Ab-1Anti-TNFAIP3 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T56474-Ab-2Anti-TNFAIP3 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T56474-Ag-1tumor necrosis factor, alpha-induced protein 3 (TNFAIP3)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T56474-Ab-1Anti-TNFAIP3 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T56474-Ab-2Anti-TNFAIP3 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T56474-Ag-1tumor necrosis factor, alpha-induced protein 3 (TNFAIP3)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T56474-Ab-1Anti-TNFAIP3 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T56474-Ab-2Anti-TNFAIP3 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T56474-Ag-1tumor necrosis factor, alpha-induced protein 3 (TNFAIP3)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T56474-Ab-1Anti-TNFAIP3 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T56474-Ab-2Anti-TNFAIP3 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameTNFAIP3
Full nametumor necrosis factor, alpha-induced protein 3
Gene ID7128
Gene NameTNFAIP3
Gene AliasA20, AISBL, OTUD7C, TNFA1P2
Protein Sub-locationIntrocelluar Protein

Antigen Information

Cat No.GM-Tg-hg-T56474-Ag-1, GM-Tg-rg-T56474-Ag-1, GM-Tg-mg-T56474-Ag-1, GM-Tg-cynog-T56474-Ag-1
Products Nametumor necrosis factor, alpha-induced protein 3 (TNFAIP3) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T56474-Ab-1, GM-Tg-hg-T56474-Ab-2,
GM-Tg-rg-T56474-Ab-1, GM-Tg-rg-T56474-Ab-2,
GM-Tg-mg-T56474-Ab-1, GM-Tg-mg-T56474-Ab-2,
GM-Tg-cynog-T56474-Ab-1, GM-Tg-cynog-T56474-Ab-2
Products NameAnti-TNFAIP3 monoclonal antibody
Formatmab
Category of antibodyTherapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-TNFAIP3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.