human, Cynomolgus/ Rhesus macaque, rat, mouse Fas ligand (TNF superfamily, member 6)(FASL) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse Fas ligand (TNF superfamily, member 6) (FASL) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Fas-mediated apoptosis proceeds through the extrinsic pathway via the binding to their respective receptors of ligands, such as FasL, tumor necrosis factor-alpha (TNF-α), lymphotoxin-alpha (LT-α), TNF-like protein-1A (TL1A), and Apo2L/TNF-related apoptosis-inducing ligand (TRAIL). FasL is the ligand for the Fas receptor. TNF-α and LT-α are ligands for the TNF superfamily member 1A (TNFR1), TL1A is a ligand for TNF receptor superfamily member 25 (DR3), and TRAIL is a ligand for the TNF receptor superfamily member 10a (DR4/TRAIL-R1) or tumor necrosis factor receptor superfamily member 10b (DR5/TRAIL-R2). These receptors are members of a subset of the TNF receptor super family known as DRs. Engagement of DRs of their cognate ligands promotes recruitment and activation of the apoptosis-initiating proteases caspase-8 and caspase-10 within membrane receptor complexes. This gene is involved in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus; pancreatic cancer; and pre-eclampsia.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T64245-Ag-1Fas ligand (TNF superfamily, member 6) (FASL) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T64245-Ab-1Anti-FASL monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T64245-Ab-2Anti-FASL monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T64245-Ag-1Fas ligand (TNF superfamily, member 6) (FASL)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T64245-Ab-1Anti-FASL monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T64245-Ab-2Anti-FASL monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T64245-Ag-1Fas ligand (TNF superfamily, member 6) (FASL)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T64245-Ab-1Anti-FASL monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T64245-Ab-2Anti-FASL monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T64245-Ag-1Fas ligand (TNF superfamily, member 6) (FASL)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T64245-Ab-1Anti-FASL monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T64245-Ab-2Anti-FASL monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameFASL
Full nameFas ligand (TNF superfamily, member 6)
Gene ID356
Gene NameFASL
Gene AliasALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T64245-Ag-1, GM-Tg-rg-T64245-Ag-1, GM-Tg-mg-T64245-Ag-1, GM-Tg-cynog-T64245-Ag-1
Products NameFas ligand (TNF superfamily, member 6) (FASL) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse Fas ligand (TNF superfamily, member 6) (FASL) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T64245-Ab-1, GM-Tg-hg-T64245-Ab-2,
GM-Tg-rg-T64245-Ab-1, GM-Tg-rg-T64245-Ab-2,
GM-Tg-mg-T64245-Ab-1, GM-Tg-mg-T64245-Ab-2,
GM-Tg-cynog-T64245-Ab-1, GM-Tg-cynog-T64245-Ab-2
Products NameAnti-CD178/FASLG monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD178 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.