human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor receptor superfamily, member 10b(TNFRSF10B) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-T70067-Ag-1tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T70067-Ab-1Anti-TNFRSF10B monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T70067-Ab-2Anti-TNFRSF10B monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T70067-Ag-1tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T70067-Ab-1Anti-TNFRSF10B monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T70067-Ab-2Anti-TNFRSF10B monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T70067-Ag-1tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T70067-Ab-1Anti-TNFRSF10B monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T70067-Ab-2Anti-TNFRSF10B monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T70067-Ag-1tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T70067-Ab-1Anti-TNFRSF10B monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T70067-Ab-2Anti-TNFRSF10B monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameTNFRSF10B
Full nametumor necrosis factor receptor superfamily, member 10b
Gene ID8795
Gene NameTNFRSF10B
Gene AliasCD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T70067-Ag-1, GM-Tg-rg-T70067-Ag-1, GM-Tg-mg-T70067-Ag-1, GM-Tg-cynog-T70067-Ag-1
Products Nametumor necrosis factor receptor superfamily, member 10b (TNFRSF10B) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T70067-Ab-1, GM-Tg-hg-T70067-Ab-2,
GM-Tg-rg-T70067-Ab-1, GM-Tg-rg-T70067-Ab-2,
GM-Tg-mg-T70067-Ab-1, GM-Tg-mg-T70067-Ab-2,
GM-Tg-cynog-T70067-Ab-1, GM-Tg-cynog-T70067-Ab-2
Products NameAnti-TRAIL-R2/TNFRSF10B monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TRAIL-R2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.