human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 1, antagonist of FGF signaling (Drosophila)(SPRY1) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

A number of MAPK modulators have been identified, including Sprouty (Spry) proteins. The Spry family members are products of four genes located on different chromosomes and differ in their tissue distribution, activity, and interaction partners. Sprouty (Spry) was first identified in a genetic screen in Drosophila to be an antagonist of fibroblast growth factor and epidermal growth factor (EGF) signaling, seemingly by inhibiting the Ras/MAP kinase pathway.  Spry proteins are not able to fully complement each other, and their biological function is likely to be dependent on tissue and cell type context. Although Spry proteins have been found to interact with several Ras–MAPK pathway components. Sprouty 1 (SPRY1) modulates the microenvironment to enable proper mammary branching morphogenesis. This process occurs through negative regulation of epidermal growth factor receptor (EGFR) signaling in mammary stroma. Spry1 was initially identified as an inhibitor of the Ras–MAPK pathway in Drosophila melanogaster. Surprisingly, subsequent studies demonstrated that Spry proteins not only inhibited Ras–MAPK pathway but also enhanced the activation of this pathway. Spry1 function in cancer has proven elusive, and it is likely dependent on tumor type, and genetic context. In fact, although a reduced expression of Spry1 was found in sarcoma, liver, ovarian, and prostate cancers, accumulating evidence indicate that up-regulation of Spry proteins, including Spry1, can promote the growth of various tumors harboring Raf or Ras mutations where they act as enhancers rather than as inhibitors of the Ras–MAPK pathway.


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T76540-Ag-1sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T76540-Ab-1Anti-SPRY1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T76540-Ab-2Anti-SPRY1 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T76540-Ag-1sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T76540-Ab-1Anti-SPRY1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T76540-Ab-2Anti-SPRY1 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T76540-Ag-1sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T76540-Ab-1Anti-SPRY1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T76540-Ab-2Anti-SPRY1 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T76540-Ag-1sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T76540-Ab-1Anti-SPRY1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T76540-Ab-2Anti-SPRY1 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameSPRY1
Full namesprouty homolog 1, antagonist of FGF signaling (Drosophila)
Gene ID10252
Gene NameSPRY1
Gene AliashSPRY1
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T76540-Ag-1, GM-Tg-rg-T76540-Ag-1, GM-Tg-mg-T76540-Ag-1, GM-Tg-cynog-T76540-Ag-1
Products Namesprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T76540-Ab-1, GM-Tg-hg-T76540-Ab-2,
GM-Tg-rg-T76540-Ab-1, GM-Tg-rg-T76540-Ab-2,
GM-Tg-mg-T76540-Ab-1, GM-Tg-mg-T76540-Ab-2,
GM-Tg-cynog-T76540-Ab-1, GM-Tg-cynog-T76540-Ab-2
Products NameAnti-SPRY-1/SPRY1 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPRY-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.