human, Cynomolgus/ Rhesus macaque, rat, mouse ciliary neurotrophic factor(CNTF) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse ciliary neurotrophic factor (CNTF) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene. Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor. CNTF has also been shown to be expressed by cells on the bone surface, and to reduce the activity of bone-forming cells (osteoblasts).


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T83192-Ag-1ciliary neurotrophic factor (CNTF) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T83192-Ab-1Anti-CNTF monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T83192-Ab-2Anti-CNTF monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T83192-Ag-1ciliary neurotrophic factor (CNTF)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T83192-Ab-1Anti-CNTF monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T83192-Ab-2Anti-CNTF monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T83192-Ag-1ciliary neurotrophic factor (CNTF)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T83192-Ab-1Anti-CNTF monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T83192-Ab-2Anti-CNTF monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T83192-Ag-1ciliary neurotrophic factor (CNTF)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T83192-Ab-1Anti-CNTF monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T83192-Ab-2Anti-CNTF monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameCNTF
Full nameciliary neurotrophic factor
Gene ID1270
Gene NameCNTF
Gene AliasHCNTF
Protein Sub-locationIntrocelluar Protein

Antigen Information

Cat No.GM-Tg-hg-T83192-Ag-1, GM-Tg-rg-T83192-Ag-1, GM-Tg-mg-T83192-Ag-1, GM-Tg-cynog-T83192-Ag-1
Products Nameciliary neurotrophic factor (CNTF) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse ciliary neurotrophic factor (CNTF) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T83192-Ab-1, GM-Tg-hg-T83192-Ab-2,
GM-Tg-rg-T83192-Ab-1, GM-Tg-rg-T83192-Ab-2,
GM-Tg-mg-T83192-Ab-1, GM-Tg-mg-T83192-Ab-2,
GM-Tg-cynog-T83192-Ab-1, GM-Tg-cynog-T83192-Ab-2
Products NameAnti-CNTF monoclonal antibody
Formatmab
Category of antibodyTherapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-CNTF monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.