human, Cynomolgus/ Rhesus macaque, rat, mouse interleukin 6 signal transducer(IL6ST) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


Target products collectionGo to IL6ST/IL6ST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse interleukin 6 signal transducer (IL6ST) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.


Order information


* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry

Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-TA093-Ag-1interleukin 6 signal transducer (IL6ST) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-TA093-Ab-1Anti-IL6ST monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-TA093-Ab-2Anti-IL6ST monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-TA093-Ag-1interleukin 6 signal transducer (IL6ST)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-TA093-Ab-1Anti-IL6ST monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-TA093-Ab-2Anti-IL6ST monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-TA093-Ag-1interleukin 6 signal transducer (IL6ST)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-TA093-Ab-1Anti-IL6ST monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-TA093-Ab-2Anti-IL6ST monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-TA093-Ag-1interleukin 6 signal transducer (IL6ST)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-TA093-Ab-1Anti-IL6ST monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-TA093-Ab-2Anti-IL6ST monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameIL6ST
Full nameinterleukin 6 signal transducer
Gene ID3572
Gene NameIL6ST
Gene AliasCD130, CDW130, GP130, IL-6RB
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-TA093-Ag-1, GM-Tg-rg-TA093-Ag-1, GM-Tg-mg-TA093-Ag-1, GM-Tg-cynog-TA093-Ag-1
Products Nameinterleukin 6 signal transducer (IL6ST) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse interleukin 6 signal transducer (IL6ST) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-TA093-Ab-1, GM-Tg-hg-TA093-Ab-2,
GM-Tg-rg-TA093-Ab-1, GM-Tg-rg-TA093-Ab-2,
GM-Tg-mg-TA093-Ab-1, GM-Tg-mg-TA093-Ab-2,
GM-Tg-cynog-TA093-Ab-1, GM-Tg-cynog-TA093-Ab-2
Products NameAnti-IL6ST monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL6ST benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.