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Anti-I27RA/ IL27R/ IL27RA monoclonal antibody
Anti-I27RA/ IL27R/ IL27RA antibody for FACS & in-vivo assay
Go to IL27R/IL27RA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IO077-Ab-1/ GM-Tg-hg-IO077-Ab-2 | Anti-Human IL27R/IL27RA monoclonal antibody | Human |
| GM-Tg-rg-IO077-Ab-1/ GM-Tg-rg-IO077-Ab-2 | Anti-Rat IL27R/IL27RA monoclonal antibody | Rat |
| GM-Tg-mg-IO077-Ab-1/ GM-Tg-mg-IO077-Ab-2 | Anti-Mouse IL27R/IL27RA monoclonal antibody | Mouse |
| GM-Tg-cynog-IO077-Ab-1/ GM-Tg-cynog-IO077-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL27R/IL27RA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IO077-Ab-1/ GM-Tg-felg-IO077-Ab-2 | Anti-Feline IL27R/IL27RA monoclonal antibody | Feline |
| GM-Tg-cang-IO077-Ab-1/ GM-Tg-cang-IO077-Ab-2 | Anti-Canine IL27R/IL27RA monoclonal antibody | Canine |
| GM-Tg-bovg-IO077-Ab-1/ GM-Tg-bovg-IO077-Ab-2 | Anti-Bovine IL27R/IL27RA monoclonal antibody | Bovine |
| GM-Tg-equg-IO077-Ab-1/ GM-Tg-equg-IO077-Ab-2 | Anti-Equine IL27R/IL27RA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IO077-Ab-1/ GM-Tg-hg-IO077-Ab-2; GM-Tg-rg-IO077-Ab-1/ GM-Tg-rg-IO077-Ab-2; GM-Tg-mg-IO077-Ab-1/ GM-Tg-mg-IO077-Ab-2; GM-Tg-cynog-IO077-Ab-1/ GM-Tg-cynog-IO077-Ab-2; GM-Tg-felg-IO077-Ab-1/ GM-Tg-felg-IO077-Ab-2; GM-Tg-cang-IO077-Ab-1/ GM-Tg-cang-IO077-Ab-2; GM-Tg-bovg-IO077-Ab-1/ GM-Tg-bovg-IO077-Ab-2; GM-Tg-equg-IO077-Ab-1/ GM-Tg-equg-IO077-Ab-2 |
| Products Name | Anti-IL27R/IL27RA monoclonal antibody |
| Format | mab |
| Target Name | IL27R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL27R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species I27RA/ IL27R/ IL27RA VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-IO077-Ag-1 | interleukin 27 receptor, alpha (IL27RA) protein |
Target information
| Target ID | GM-IO077 |
| Target Name | IL27R |
| Gene ID | 9466,50931,288905,717549,484907,101089988,514529,102150342 |
| Gene Symbol and Synonyms | CRL1,IL-27R,IL-27RA,IL27R,IL27RA,TCCR,WSX-1,WSX1,zcytor1 |
| Uniprot Accession | Q6UWB1 |
| Uniprot Entry Name | I27RA_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000104998 |
| Target Classification | Checkpoint-Immuno Oncology, Cytokine Receptor |
The target: IL27R, gene name: IL27RA, also named as CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1. In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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