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Anti-BAX monoclonal antibody
Pre-made anti-BAX monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to BAX/BAX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0034-Ab-1/ GM-Tg-hg-IP0034-Ab-2 | Anti-Human BAX monoclonal antibody | Human |
| GM-Tg-rg-IP0034-Ab-1/ GM-Tg-rg-IP0034-Ab-2 | Anti-Rat BAX monoclonal antibody | Rat |
| GM-Tg-mg-IP0034-Ab-1/ GM-Tg-mg-IP0034-Ab-2 | Anti-Mouse BAX monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0034-Ab-1/ GM-Tg-cynog-IP0034-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BAX monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0034-Ab-1/ GM-Tg-felg-IP0034-Ab-2 | Anti-Feline BAX monoclonal antibody | Feline |
| GM-Tg-cang-IP0034-Ab-1/ GM-Tg-cang-IP0034-Ab-2 | Anti-Canine BAX monoclonal antibody | Canine |
| GM-Tg-bovg-IP0034-Ab-1/ GM-Tg-bovg-IP0034-Ab-2 | Anti-Bovine BAX monoclonal antibody | Bovine |
| GM-Tg-equg-IP0034-Ab-1/ GM-Tg-equg-IP0034-Ab-2 | Anti-Equine BAX monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0034-Ab-1/ GM-Tg-hg-IP0034-Ab-2; GM-Tg-rg-IP0034-Ab-1/ GM-Tg-rg-IP0034-Ab-2; GM-Tg-mg-IP0034-Ab-1/ GM-Tg-mg-IP0034-Ab-2; GM-Tg-cynog-IP0034-Ab-1/ GM-Tg-cynog-IP0034-Ab-2; GM-Tg-felg-IP0034-Ab-1/ GM-Tg-felg-IP0034-Ab-2; GM-Tg-cang-IP0034-Ab-1/ GM-Tg-cang-IP0034-Ab-2; GM-Tg-bovg-IP0034-Ab-1/ GM-Tg-bovg-IP0034-Ab-2; GM-Tg-equg-IP0034-Ab-1/ GM-Tg-equg-IP0034-Ab-2 |
| Products Name | Anti-BAX monoclonal antibody |
| Format | mab |
| Target Name | BAX |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-BAX monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0034-Ag-1 | Recombinant multi-species BAX/ BCL2L4 protein |
| ORF Viral Vector | vGMAD000113 | human BAX Adenovirus particle |
| ORF Viral Vector | vGMAP000055 | Human BAX Adenovirus particle |
| ORF Viral Vector | pGMAD000113 | human BAX Adenovirus plasmid |
| ORF Viral Vector | pGMAP000055 | Human BAX Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000003 | mouse Bax Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000003 | mouse Bax Lentivirus particle |
Target information
| Target ID | GM-IP0034 |
| Target Name | BAX |
| Gene ID | 581,12028,24887,718948,403523,493837,280730,100054674 |
| Gene Symbol and Synonyms | BAX,BCL2L4 |
| Uniprot Accession | Q07812,Q63690,O02703 |
| Uniprot Entry Name | BAX_HUMAN,BAX_RAT,BAX_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000087088 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: BAX, gene name: BAX, also named as BCL2L4. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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