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Anti-USP20 monoclonal antibody
Pre-made anti-USP20 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to USP20/USP20 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0036-Ab-1/ GM-Tg-hg-IP0036-Ab-2 | Anti-Human USP20 monoclonal antibody | Human |
| GM-Tg-rg-IP0036-Ab-1/ GM-Tg-rg-IP0036-Ab-2 | Anti-Rat USP20 monoclonal antibody | Rat |
| GM-Tg-mg-IP0036-Ab-1/ GM-Tg-mg-IP0036-Ab-2 | Anti-Mouse USP20 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0036-Ab-1/ GM-Tg-cynog-IP0036-Ab-2 | Anti-Cynomolgus/ Rhesus macaque USP20 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0036-Ab-1/ GM-Tg-felg-IP0036-Ab-2 | Anti-Feline USP20 monoclonal antibody | Feline |
| GM-Tg-cang-IP0036-Ab-1/ GM-Tg-cang-IP0036-Ab-2 | Anti-Canine USP20 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0036-Ab-1/ GM-Tg-bovg-IP0036-Ab-2 | Anti-Bovine USP20 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0036-Ab-1/ GM-Tg-equg-IP0036-Ab-2 | Anti-Equine USP20 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0036-Ab-1/ GM-Tg-hg-IP0036-Ab-2; GM-Tg-rg-IP0036-Ab-1/ GM-Tg-rg-IP0036-Ab-2; GM-Tg-mg-IP0036-Ab-1/ GM-Tg-mg-IP0036-Ab-2; GM-Tg-cynog-IP0036-Ab-1/ GM-Tg-cynog-IP0036-Ab-2; GM-Tg-felg-IP0036-Ab-1/ GM-Tg-felg-IP0036-Ab-2; GM-Tg-cang-IP0036-Ab-1/ GM-Tg-cang-IP0036-Ab-2; GM-Tg-bovg-IP0036-Ab-1/ GM-Tg-bovg-IP0036-Ab-2; GM-Tg-equg-IP0036-Ab-1/ GM-Tg-equg-IP0036-Ab-2 |
| Products Name | Anti-USP20 monoclonal antibody |
| Format | mab |
| Target Name | USP20 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-USP20 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0036-Ag-1 | Recombinant multi-species UBP20/ USP20/ LSFR3A protein |
Target information
| Target ID | GM-IP0036 |
| Target Name | USP20 |
| Gene ID | 10868,74270,311856,716505,480696,101086431,505839,100066778 |
| Gene Symbol and Synonyms | 1700055M05Rik,hVDU2,LSFR3A,USP20,VDU2 |
| Uniprot Accession | Q9Y2K6,A7Z056 |
| Uniprot Entry Name | UBP20_HUMAN,UBP20_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000136878 |
| Target Classification | N/A |
The target: USP20, gene name: USP20, also named as LSFR3A, VDU2, hVDU2. This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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