Anti-PTGES monoclonal antibody
Pre-made anti-PTGES monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-IP0039-Ab-1/ GM-Tg-hg-IP0039-Ab-2 | Anti-Human PTGES monoclonal antibody | Human |
GM-Tg-rg-IP0039-Ab-1/ GM-Tg-rg-IP0039-Ab-2 | Anti-Rat PTGES monoclonal antibody | Rat |
GM-Tg-mg-IP0039-Ab-1/ GM-Tg-mg-IP0039-Ab-2 | Anti-Mouse PTGES monoclonal antibody | Mouse |
GM-Tg-cynog-IP0039-Ab-1/ GM-Tg-cynog-IP0039-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTGES monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-IP0039-Ab-1/ GM-Tg-felg-IP0039-Ab-2 | Anti-Feline PTGES monoclonal antibody | Feline |
GM-Tg-cang-IP0039-Ab-1/ GM-Tg-cang-IP0039-Ab-2 | Anti-Canine PTGES monoclonal antibody | Canine |
GM-Tg-bovg-IP0039-Ab-1/ GM-Tg-bovg-IP0039-Ab-2 | Anti-Bovine PTGES monoclonal antibody | Bovine |
GM-Tg-equg-IP0039-Ab-1/ GM-Tg-equg-IP0039-Ab-2 | Anti-Equine PTGES monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-IP0039-Ab-1/ GM-Tg-hg-IP0039-Ab-2; GM-Tg-rg-IP0039-Ab-1/ GM-Tg-rg-IP0039-Ab-2; GM-Tg-mg-IP0039-Ab-1/ GM-Tg-mg-IP0039-Ab-2; GM-Tg-cynog-IP0039-Ab-1/ GM-Tg-cynog-IP0039-Ab-2; GM-Tg-felg-IP0039-Ab-1/ GM-Tg-felg-IP0039-Ab-2; GM-Tg-cang-IP0039-Ab-1/ GM-Tg-cang-IP0039-Ab-2; GM-Tg-bovg-IP0039-Ab-1/ GM-Tg-bovg-IP0039-Ab-2; GM-Tg-equg-IP0039-Ab-1/ GM-Tg-equg-IP0039-Ab-2 |
Products Name | Anti-PTGES monoclonal antibody |
Format | mab |
Target Name | PTGES |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-PTGES monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-IP0039-Ag-1 | Recombinant multi-species PTGES/ MGST-IV/ MGST1-L1 protein |
ORF Viral Vector | vGMLP000341 | human PTGES Lentivirus particle |
ORF Viral Vector | pGMLP000341 | human PTGES Lentivirus plasmid |
ORF Viral Vector | pGMAAV000190 | house mouse Ptges AAV plasmid |
ORF Viral Vector | pGMLPm000164 | mouse Ptges Lentivirus plasmid |
ORF Viral Vector | vGMAAV000190 | house mouse Ptges AAV particle |
ORF Viral Vector | vGMLPm000164 | mouse Ptges Lentivirus particle |
Target information
Target ID | GM-IP0039 |
Target Name | PTGES |
Gene ID | 9536,64292,59103,716657,480698,101086187,282019,100034143 |
Gene Symbol and Synonyms | 2410099E23Rik,D2Ertd369e,MGST-IV,MGST1-L1,MGST1L1,MPGES,mPGES-1,PGES,PIG12,PP102,PP1294,PTGES,TP53I12 |
Uniprot Accession | O14684,Q9JHF3,A0SYQ0,Q95L14,Q8HZJ2 |
Uniprot Entry Name | PTGES_HUMAN,PTGES_RAT,PTGES_CANLF,PTGES_BOVIN,PTGES_HORSE |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000148344 |
Target Classification | N/A |
The target: PTGES, gene name: PTGES, also named as MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.