Anti-PTGES monoclonal antibody

Pre-made anti-PTGES monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PTGES/PTGES products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0039-Ab-1/ GM-Tg-hg-IP0039-Ab-2Anti-Human PTGES monoclonal antibodyHuman
GM-Tg-rg-IP0039-Ab-1/ GM-Tg-rg-IP0039-Ab-2Anti-Rat PTGES monoclonal antibodyRat
GM-Tg-mg-IP0039-Ab-1/ GM-Tg-mg-IP0039-Ab-2Anti-Mouse PTGES monoclonal antibodyMouse
GM-Tg-cynog-IP0039-Ab-1/ GM-Tg-cynog-IP0039-Ab-2Anti-Cynomolgus/ Rhesus macaque PTGES monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0039-Ab-1/ GM-Tg-felg-IP0039-Ab-2Anti-Feline PTGES monoclonal antibodyFeline
GM-Tg-cang-IP0039-Ab-1/ GM-Tg-cang-IP0039-Ab-2Anti-Canine PTGES monoclonal antibodyCanine
GM-Tg-bovg-IP0039-Ab-1/ GM-Tg-bovg-IP0039-Ab-2Anti-Bovine PTGES monoclonal antibodyBovine
GM-Tg-equg-IP0039-Ab-1/ GM-Tg-equg-IP0039-Ab-2Anti-Equine PTGES monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0039-Ab-1/ GM-Tg-hg-IP0039-Ab-2; GM-Tg-rg-IP0039-Ab-1/ GM-Tg-rg-IP0039-Ab-2;
GM-Tg-mg-IP0039-Ab-1/ GM-Tg-mg-IP0039-Ab-2; GM-Tg-cynog-IP0039-Ab-1/ GM-Tg-cynog-IP0039-Ab-2;
GM-Tg-felg-IP0039-Ab-1/ GM-Tg-felg-IP0039-Ab-2; GM-Tg-cang-IP0039-Ab-1/ GM-Tg-cang-IP0039-Ab-2;
GM-Tg-bovg-IP0039-Ab-1/ GM-Tg-bovg-IP0039-Ab-2; GM-Tg-equg-IP0039-Ab-1/ GM-Tg-equg-IP0039-Ab-2
Products NameAnti-PTGES monoclonal antibody
Formatmab
Target NamePTGES
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PTGES monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0039-Ag-1Recombinant multi-species PTGES/ MGST-IV/ MGST1-L1 protein
    ORF Viral VectorvGMLP000341human PTGES Lentivirus particle
    ORF Viral VectorpGMLP000341human PTGES Lentivirus plasmid
    ORF Viral VectorpGMAAV000190house mouse Ptges AAV plasmid
    ORF Viral VectorpGMLPm000164mouse Ptges Lentivirus plasmid
    ORF Viral VectorvGMAAV000190house mouse Ptges AAV particle
    ORF Viral VectorvGMLPm000164mouse Ptges Lentivirus particle


    Target information

    Target IDGM-IP0039
    Target NamePTGES
    Gene ID9536,64292,59103,716657,480698,101086187,282019,100034143
    Gene Symbol and Synonyms2410099E23Rik,D2Ertd369e,MGST-IV,MGST1-L1,MGST1L1,MPGES,mPGES-1,PGES,PIG12,PP102,PP1294,PTGES,TP53I12
    Uniprot AccessionO14684,Q9JHF3,A0SYQ0,Q95L14,Q8HZJ2
    Uniprot Entry NamePTGES_HUMAN,PTGES_RAT,PTGES_CANLF,PTGES_BOVIN,PTGES_HORSE
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000148344
    Target ClassificationN/A

    The target: PTGES, gene name: PTGES, also named as MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.