Anti-HSD11B1 monoclonal antibody
Pre-made anti-HSD11B1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-IP0040-Ab-1/ GM-Tg-hg-IP0040-Ab-2 | Anti-Human HSD11B1 monoclonal antibody | Human |
GM-Tg-rg-IP0040-Ab-1/ GM-Tg-rg-IP0040-Ab-2 | Anti-Rat HSD11B1 monoclonal antibody | Rat |
GM-Tg-mg-IP0040-Ab-1/ GM-Tg-mg-IP0040-Ab-2 | Anti-Mouse HSD11B1 monoclonal antibody | Mouse |
GM-Tg-cynog-IP0040-Ab-1/ GM-Tg-cynog-IP0040-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HSD11B1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-IP0040-Ab-1/ GM-Tg-felg-IP0040-Ab-2 | Anti-Feline HSD11B1 monoclonal antibody | Feline |
GM-Tg-cang-IP0040-Ab-1/ GM-Tg-cang-IP0040-Ab-2 | Anti-Canine HSD11B1 monoclonal antibody | Canine |
GM-Tg-bovg-IP0040-Ab-1/ GM-Tg-bovg-IP0040-Ab-2 | Anti-Bovine HSD11B1 monoclonal antibody | Bovine |
GM-Tg-equg-IP0040-Ab-1/ GM-Tg-equg-IP0040-Ab-2 | Anti-Equine HSD11B1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-IP0040-Ab-1/ GM-Tg-hg-IP0040-Ab-2; GM-Tg-rg-IP0040-Ab-1/ GM-Tg-rg-IP0040-Ab-2; GM-Tg-mg-IP0040-Ab-1/ GM-Tg-mg-IP0040-Ab-2; GM-Tg-cynog-IP0040-Ab-1/ GM-Tg-cynog-IP0040-Ab-2; GM-Tg-felg-IP0040-Ab-1/ GM-Tg-felg-IP0040-Ab-2; GM-Tg-cang-IP0040-Ab-1/ GM-Tg-cang-IP0040-Ab-2; GM-Tg-bovg-IP0040-Ab-1/ GM-Tg-bovg-IP0040-Ab-2; GM-Tg-equg-IP0040-Ab-1/ GM-Tg-equg-IP0040-Ab-2 |
Products Name | Anti-HSD11B1 monoclonal antibody |
Format | mab |
Target Name | HSD11B1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-HSD11B1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-IP0040-Ag-1 | Recombinant multi-species DHI1/ HSD11B1/ 11-DH protein |
ORF Viral Vector | vGMLP002767 | human HSD11B1 Lentivirus particle |
ORF Viral Vector | pGMLP002767 | human HSD11B1 Lentivirus plasmid |
ORF Viral Vector | pGMLPm000390 | mouse Hsd11b1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm000390 | mouse Hsd11b1 Lentivirus particle |
Target information
Target ID | GM-IP0040 |
Target Name | HSD11B1 |
Gene ID | 3290,15483,25116,574322,449023,100529248,282589,100056429 |
Gene Symbol and Synonyms | 11-beta-HSD1,11-DH,11HSD1,CORTRD2,HDL,HSD11,HSD11B,HSD11B1,HSD11L,LRRGT00065,SDR26C1 |
Uniprot Accession | P28845,P16232,Q8HZJ8 |
Uniprot Entry Name | DHI1_HUMAN,DHI1_RAT,DHI1_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000117594 |
Target Classification | Tumor-associated antigen (TAA) |
The target: HSD11B1, gene name: HSD11B1, also named as 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.