Anti-HSD11B1 monoclonal antibody

Pre-made anti-HSD11B1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to HSD11B1/HSD11B1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0040-Ab-1/ GM-Tg-hg-IP0040-Ab-2Anti-Human HSD11B1 monoclonal antibodyHuman
GM-Tg-rg-IP0040-Ab-1/ GM-Tg-rg-IP0040-Ab-2Anti-Rat HSD11B1 monoclonal antibodyRat
GM-Tg-mg-IP0040-Ab-1/ GM-Tg-mg-IP0040-Ab-2Anti-Mouse HSD11B1 monoclonal antibodyMouse
GM-Tg-cynog-IP0040-Ab-1/ GM-Tg-cynog-IP0040-Ab-2Anti-Cynomolgus/ Rhesus macaque HSD11B1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0040-Ab-1/ GM-Tg-felg-IP0040-Ab-2Anti-Feline HSD11B1 monoclonal antibodyFeline
GM-Tg-cang-IP0040-Ab-1/ GM-Tg-cang-IP0040-Ab-2Anti-Canine HSD11B1 monoclonal antibodyCanine
GM-Tg-bovg-IP0040-Ab-1/ GM-Tg-bovg-IP0040-Ab-2Anti-Bovine HSD11B1 monoclonal antibodyBovine
GM-Tg-equg-IP0040-Ab-1/ GM-Tg-equg-IP0040-Ab-2Anti-Equine HSD11B1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0040-Ab-1/ GM-Tg-hg-IP0040-Ab-2; GM-Tg-rg-IP0040-Ab-1/ GM-Tg-rg-IP0040-Ab-2;
GM-Tg-mg-IP0040-Ab-1/ GM-Tg-mg-IP0040-Ab-2; GM-Tg-cynog-IP0040-Ab-1/ GM-Tg-cynog-IP0040-Ab-2;
GM-Tg-felg-IP0040-Ab-1/ GM-Tg-felg-IP0040-Ab-2; GM-Tg-cang-IP0040-Ab-1/ GM-Tg-cang-IP0040-Ab-2;
GM-Tg-bovg-IP0040-Ab-1/ GM-Tg-bovg-IP0040-Ab-2; GM-Tg-equg-IP0040-Ab-1/ GM-Tg-equg-IP0040-Ab-2
Products NameAnti-HSD11B1 monoclonal antibody
Formatmab
Target NameHSD11B1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-HSD11B1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0040-Ag-1Recombinant multi-species DHI1/ HSD11B1/ 11-DH protein
    ORF Viral VectorvGMLP002767human HSD11B1 Lentivirus particle
    ORF Viral VectorpGMLP002767human HSD11B1 Lentivirus plasmid
    ORF Viral VectorpGMLPm000390mouse Hsd11b1 Lentivirus plasmid
    ORF Viral VectorvGMLPm000390mouse Hsd11b1 Lentivirus particle


    Target information

    Target IDGM-IP0040
    Target NameHSD11B1
    Gene ID3290,15483,25116,574322,449023,100529248,282589,100056429
    Gene Symbol and Synonyms11-beta-HSD1,11-DH,11HSD1,CORTRD2,HDL,HSD11,HSD11B,HSD11B1,HSD11L,LRRGT00065,SDR26C1
    Uniprot AccessionP28845,P16232,Q8HZJ8
    Uniprot Entry NameDHI1_HUMAN,DHI1_RAT,DHI1_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000117594
    Target ClassificationTumor-associated antigen (TAA)

    The target: HSD11B1, gene name: HSD11B1, also named as 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.