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Anti-VDUP1 monoclonal antibody
Pre-made anti-VDUP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to VDUP1/TXNIP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0163-Ab-1/ GM-Tg-hg-IP0163-Ab-2 | Anti-Human VDUP1/TXNIP monoclonal antibody | Human |
| GM-Tg-rg-IP0163-Ab-1/ GM-Tg-rg-IP0163-Ab-2 | Anti-Rat VDUP1/TXNIP monoclonal antibody | Rat |
| GM-Tg-mg-IP0163-Ab-1/ GM-Tg-mg-IP0163-Ab-2 | Anti-Mouse VDUP1/TXNIP monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0163-Ab-1/ GM-Tg-cynog-IP0163-Ab-2 | Anti-Cynomolgus/ Rhesus macaque VDUP1/TXNIP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0163-Ab-1/ GM-Tg-felg-IP0163-Ab-2 | Anti-Feline VDUP1/TXNIP monoclonal antibody | Feline |
| GM-Tg-cang-IP0163-Ab-1/ GM-Tg-cang-IP0163-Ab-2 | Anti-Canine VDUP1/TXNIP monoclonal antibody | Canine |
| GM-Tg-bovg-IP0163-Ab-1/ GM-Tg-bovg-IP0163-Ab-2 | Anti-Bovine VDUP1/TXNIP monoclonal antibody | Bovine |
| GM-Tg-equg-IP0163-Ab-1/ GM-Tg-equg-IP0163-Ab-2 | Anti-Equine VDUP1/TXNIP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0163-Ab-1/ GM-Tg-hg-IP0163-Ab-2; GM-Tg-rg-IP0163-Ab-1/ GM-Tg-rg-IP0163-Ab-2; GM-Tg-mg-IP0163-Ab-1/ GM-Tg-mg-IP0163-Ab-2; GM-Tg-cynog-IP0163-Ab-1/ GM-Tg-cynog-IP0163-Ab-2; GM-Tg-felg-IP0163-Ab-1/ GM-Tg-felg-IP0163-Ab-2; GM-Tg-cang-IP0163-Ab-1/ GM-Tg-cang-IP0163-Ab-2; GM-Tg-bovg-IP0163-Ab-1/ GM-Tg-bovg-IP0163-Ab-2; GM-Tg-equg-IP0163-Ab-1/ GM-Tg-equg-IP0163-Ab-2 |
| Products Name | Anti-VDUP1/TXNIP monoclonal antibody |
| Format | mab |
| Target Name | VDUP1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-VDUP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0163-Ag-1 | Recombinant multi-species TXNIP/ VDUP1/ ARRDC6 protein |
| ORF Viral Vector | pGMLV000188 | human TXNIP Lentivirus plasmid |
| ORF Viral Vector | pGMAP000591 | human TXNIP Adenovirus plasmid |
| ORF Viral Vector | vGMAP000591 | human TXNIP Adenovirus particle |
| ORF Viral Vector | vGMLV000188 | human TXNIP Lentivirus particle |
| ORF Viral Vector | pGMAD000027 | mouse Txnip Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000006 | mouse Txnip AAV plasmid |
| ORF Viral Vector | vGMAD000027 | mouse Txnip Adenovirus particle |
| ORF Viral Vector | vGMAAV000006 | mouse Txnip AAV particle |
Target information
| Target ID | GM-IP0163 |
| Target Name | VDUP1 |
| Gene ID | 10628,56338,117514,698683,475829,101099739,506790,111773538 |
| Gene Symbol and Synonyms | 1200008J08Rik,ARRDC6,EST01027,HHCPA78,Hyplip1,Tbp-2,THIF,TXNIP,VDUP1 |
| Uniprot Accession | Q9H3M7,Q5M7W1 |
| Uniprot Entry Name | TXNIP_HUMAN,TXNIP_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000265972 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: VDUP1, gene name: TXNIP, also named as ARRDC6, EST01027, HHCPA78, THIF, VDUP1. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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