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Anti-CERS3 monoclonal antibody
Pre-made anti-CERS3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CERS3/CERS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0535-Ab-1/ GM-Tg-hg-IP0535-Ab-2 | Anti-Human CERS3 monoclonal antibody | Human |
| GM-Tg-rg-IP0535-Ab-1/ GM-Tg-rg-IP0535-Ab-2 | Anti-Rat CERS3 monoclonal antibody | Rat |
| GM-Tg-mg-IP0535-Ab-1/ GM-Tg-mg-IP0535-Ab-2 | Anti-Mouse CERS3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0535-Ab-1/ GM-Tg-cynog-IP0535-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CERS3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0535-Ab-1/ GM-Tg-felg-IP0535-Ab-2 | Anti-Feline CERS3 monoclonal antibody | Feline |
| GM-Tg-cang-IP0535-Ab-1/ GM-Tg-cang-IP0535-Ab-2 | Anti-Canine CERS3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0535-Ab-1/ GM-Tg-bovg-IP0535-Ab-2 | Anti-Bovine CERS3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0535-Ab-1/ GM-Tg-equg-IP0535-Ab-2 | Anti-Equine CERS3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0535-Ab-1/ GM-Tg-hg-IP0535-Ab-2; GM-Tg-rg-IP0535-Ab-1/ GM-Tg-rg-IP0535-Ab-2; GM-Tg-mg-IP0535-Ab-1/ GM-Tg-mg-IP0535-Ab-2; GM-Tg-cynog-IP0535-Ab-1/ GM-Tg-cynog-IP0535-Ab-2; GM-Tg-felg-IP0535-Ab-1/ GM-Tg-felg-IP0535-Ab-2; GM-Tg-cang-IP0535-Ab-1/ GM-Tg-cang-IP0535-Ab-2; GM-Tg-bovg-IP0535-Ab-1/ GM-Tg-bovg-IP0535-Ab-2; GM-Tg-equg-IP0535-Ab-1/ GM-Tg-equg-IP0535-Ab-2 |
| Products Name | Anti-CERS3 monoclonal antibody |
| Format | mab |
| Target Name | CERS3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CERS3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0535-Ag-1 | Recombinant multi-species CERS3/ ARCI9/ LASS3 protein |
| ORF Viral Vector | pGMLPm002058 | mouse Cers3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002058 | mouse Cers3 Lentivirus particle |
Target information
| Target ID | GM-IP0535 |
| Target Name | CERS3 |
| Gene ID | 204219,545975,499174,693696,607925,101099301,614354,100050135 |
| Gene Symbol and Synonyms | 4930550L11Rik,ARCI9,CERS3,Gm488,LASS3,mCerS3,RGD1564356,T3L |
| Uniprot Accession | Q8IU89 |
| Uniprot Entry Name | CERS3_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000154227 |
| Target Classification | N/A |
The target: CERS3, gene name: CERS3, also named as ARCI9, LASS3. This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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