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Anti-CLN6 monoclonal antibody
Pre-made anti-CLN6 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CLN6/CLN6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0562-Ab-1/ GM-Tg-hg-IP0562-Ab-2 | Anti-Human CLN6 monoclonal antibody | Human |
| GM-Tg-rg-IP0562-Ab-1/ GM-Tg-rg-IP0562-Ab-2 | Anti-Rat CLN6 monoclonal antibody | Rat |
| GM-Tg-mg-IP0562-Ab-1/ GM-Tg-mg-IP0562-Ab-2 | Anti-Mouse CLN6 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0562-Ab-1/ GM-Tg-cynog-IP0562-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLN6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0562-Ab-1/ GM-Tg-felg-IP0562-Ab-2 | Anti-Feline CLN6 monoclonal antibody | Feline |
| GM-Tg-cang-IP0562-Ab-1/ GM-Tg-cang-IP0562-Ab-2 | Anti-Canine CLN6 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0562-Ab-1/ GM-Tg-bovg-IP0562-Ab-2 | Anti-Bovine CLN6 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0562-Ab-1/ GM-Tg-equg-IP0562-Ab-2 | Anti-Equine CLN6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0562-Ab-1/ GM-Tg-hg-IP0562-Ab-2; GM-Tg-rg-IP0562-Ab-1/ GM-Tg-rg-IP0562-Ab-2; GM-Tg-mg-IP0562-Ab-1/ GM-Tg-mg-IP0562-Ab-2; GM-Tg-cynog-IP0562-Ab-1/ GM-Tg-cynog-IP0562-Ab-2; GM-Tg-felg-IP0562-Ab-1/ GM-Tg-felg-IP0562-Ab-2; GM-Tg-cang-IP0562-Ab-1/ GM-Tg-cang-IP0562-Ab-2; GM-Tg-bovg-IP0562-Ab-1/ GM-Tg-bovg-IP0562-Ab-2; GM-Tg-equg-IP0562-Ab-1/ GM-Tg-equg-IP0562-Ab-2 |
| Products Name | Anti-CLN6 monoclonal antibody |
| Format | mab |
| Target Name | CLN6 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CLN6 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0562-Ag-1 | Recombinant multi-species CLN6/ CLN4A/ HsT18960 protein |
| ORF Viral Vector | vGMLP000577 | human CLN6 Lentivirus particle |
| ORF Viral Vector | pGMLP000577 | human CLN6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003923 | mouse Cln6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003923 | mouse Cln6 Lentivirus particle |
Target information
| Target ID | GM-IP0562 |
| Target Name | CLN6 |
| Gene ID | 54982,76524,315746,693873,497068,101099969,617615,100065359 |
| Gene Symbol and Synonyms | 1810065L06Rik,CLN4A,CLN6,CLN6A,D9Bwg1455e,HsT18960,nclf |
| Uniprot Accession | Q9NWW5,Q5JZQ8 |
| Uniprot Entry Name | CLN6_HUMAN,CLN6_CANLF |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000128973 |
| Target Classification | N/A |
The target: CLN6, gene name: CLN6, also named as CLN4A, HsT18960, nclf. This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
