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Anti-CREB3 monoclonal antibody
Pre-made anti-CREB3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CREB3/CREB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0610-Ab-1/ GM-Tg-hg-IP0610-Ab-2 | Anti-Human CREB3 monoclonal antibody | Human |
| GM-Tg-rg-IP0610-Ab-1/ GM-Tg-rg-IP0610-Ab-2 | Anti-Rat CREB3 monoclonal antibody | Rat |
| GM-Tg-mg-IP0610-Ab-1/ GM-Tg-mg-IP0610-Ab-2 | Anti-Mouse CREB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0610-Ab-1/ GM-Tg-cynog-IP0610-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CREB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0610-Ab-1/ GM-Tg-felg-IP0610-Ab-2 | Anti-Feline CREB3 monoclonal antibody | Feline |
| GM-Tg-cang-IP0610-Ab-1/ GM-Tg-cang-IP0610-Ab-2 | Anti-Canine CREB3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0610-Ab-1/ GM-Tg-bovg-IP0610-Ab-2 | Anti-Bovine CREB3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0610-Ab-1/ GM-Tg-equg-IP0610-Ab-2 | Anti-Equine CREB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0610-Ab-1/ GM-Tg-hg-IP0610-Ab-2; GM-Tg-rg-IP0610-Ab-1/ GM-Tg-rg-IP0610-Ab-2; GM-Tg-mg-IP0610-Ab-1/ GM-Tg-mg-IP0610-Ab-2; GM-Tg-cynog-IP0610-Ab-1/ GM-Tg-cynog-IP0610-Ab-2; GM-Tg-felg-IP0610-Ab-1/ GM-Tg-felg-IP0610-Ab-2; GM-Tg-cang-IP0610-Ab-1/ GM-Tg-cang-IP0610-Ab-2; GM-Tg-bovg-IP0610-Ab-1/ GM-Tg-bovg-IP0610-Ab-2; GM-Tg-equg-IP0610-Ab-1/ GM-Tg-equg-IP0610-Ab-2 |
| Products Name | Anti-CREB3 monoclonal antibody |
| Format | mab |
| Target Name | CREB3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CREB3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0610-Ag-1 | Recombinant multi-species CREB3/ LUMAN/ LZIP protein |
| ORF Viral Vector | vGMLP003938 | human CREB3 Lentivirus particle |
| ORF Viral Vector | pGMLP003938 | human CREB3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001376 | mouse Creb3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001376 | mouse Creb3 Lentivirus particle |
Target information
| Target ID | GM-IP0610 |
| Target Name | CREB3 |
| Gene ID | 10488,12913,298400,696350,611934,101093555,281715,100067794 |
| Gene Symbol and Synonyms | CREB3,LUMAN,LZIP,LZIP-1,LZIP-2,sLZIP |
| Uniprot Accession | O43889,Q8SQ19 |
| Uniprot Entry Name | CREB3_HUMAN,CREB3_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000107175 |
| Target Classification | N/A |
The target: CREB3, gene name: CREB3, also named as LUMAN, LZIP, sLZIP. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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