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Anti-DENND1A monoclonal antibody
Pre-made anti-DENND1A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DENND1A/DENND1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0677-Ab-1/ GM-Tg-hg-IP0677-Ab-2 | Anti-Human DENND1A monoclonal antibody | Human |
| GM-Tg-rg-IP0677-Ab-1/ GM-Tg-rg-IP0677-Ab-2 | Anti-Rat DENND1A monoclonal antibody | Rat |
| GM-Tg-mg-IP0677-Ab-1/ GM-Tg-mg-IP0677-Ab-2 | Anti-Mouse DENND1A monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0677-Ab-1/ GM-Tg-cynog-IP0677-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DENND1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0677-Ab-1/ GM-Tg-felg-IP0677-Ab-2 | Anti-Feline DENND1A monoclonal antibody | Feline |
| GM-Tg-cang-IP0677-Ab-1/ GM-Tg-cang-IP0677-Ab-2 | Anti-Canine DENND1A monoclonal antibody | Canine |
| GM-Tg-bovg-IP0677-Ab-1/ GM-Tg-bovg-IP0677-Ab-2 | Anti-Bovine DENND1A monoclonal antibody | Bovine |
| GM-Tg-equg-IP0677-Ab-1/ GM-Tg-equg-IP0677-Ab-2 | Anti-Equine DENND1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0677-Ab-1/ GM-Tg-hg-IP0677-Ab-2; GM-Tg-rg-IP0677-Ab-1/ GM-Tg-rg-IP0677-Ab-2; GM-Tg-mg-IP0677-Ab-1/ GM-Tg-mg-IP0677-Ab-2; GM-Tg-cynog-IP0677-Ab-1/ GM-Tg-cynog-IP0677-Ab-2; GM-Tg-felg-IP0677-Ab-1/ GM-Tg-felg-IP0677-Ab-2; GM-Tg-cang-IP0677-Ab-1/ GM-Tg-cang-IP0677-Ab-2; GM-Tg-bovg-IP0677-Ab-1/ GM-Tg-bovg-IP0677-Ab-2; GM-Tg-equg-IP0677-Ab-1/ GM-Tg-equg-IP0677-Ab-2 |
| Products Name | Anti-DENND1A monoclonal antibody |
| Format | mab |
| Target Name | DENND1A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DENND1A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0677-Ag-1 | Recombinant multi-species DEN1A/ DENND1A/ FAM31A protein |
| ORF Viral Vector | pGMLPm004474 | mouse Dennd1a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004474 | mouse Dennd1a Lentivirus particle |
Target information
| Target ID | GM-IP0677 |
| Target Name | DENND1A |
| Gene ID | 57706,227801,311913,698028,609706,101088373,514134,100067362 |
| Gene Symbol and Synonyms | 6030446I19Rik,connecdenn,DENND1A,FAM31A,KIAA1608,RGD1307927 |
| Uniprot Accession | Q8TEH3 |
| Uniprot Entry Name | DEN1A_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000119522 |
| Target Classification | N/A |
The target: DENND1A, gene name: DENND1A, also named as FAM31A, KIAA1608. Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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