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Anti-DENND5A monoclonal antibody
Pre-made anti-DENND5A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DENND5A/DENND5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0681-Ab-1/ GM-Tg-hg-IP0681-Ab-2 | Anti-Human DENND5A monoclonal antibody | Human |
| GM-Tg-rg-IP0681-Ab-1/ GM-Tg-rg-IP0681-Ab-2 | Anti-Rat DENND5A monoclonal antibody | Rat |
| GM-Tg-mg-IP0681-Ab-1/ GM-Tg-mg-IP0681-Ab-2 | Anti-Mouse DENND5A monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0681-Ab-1/ GM-Tg-cynog-IP0681-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DENND5A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0681-Ab-1/ GM-Tg-felg-IP0681-Ab-2 | Anti-Feline DENND5A monoclonal antibody | Feline |
| GM-Tg-cang-IP0681-Ab-1/ GM-Tg-cang-IP0681-Ab-2 | Anti-Canine DENND5A monoclonal antibody | Canine |
| GM-Tg-bovg-IP0681-Ab-1/ GM-Tg-bovg-IP0681-Ab-2 | Anti-Bovine DENND5A monoclonal antibody | Bovine |
| GM-Tg-equg-IP0681-Ab-1/ GM-Tg-equg-IP0681-Ab-2 | Anti-Equine DENND5A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0681-Ab-1/ GM-Tg-hg-IP0681-Ab-2; GM-Tg-rg-IP0681-Ab-1/ GM-Tg-rg-IP0681-Ab-2; GM-Tg-mg-IP0681-Ab-1/ GM-Tg-mg-IP0681-Ab-2; GM-Tg-cynog-IP0681-Ab-1/ GM-Tg-cynog-IP0681-Ab-2; GM-Tg-felg-IP0681-Ab-1/ GM-Tg-felg-IP0681-Ab-2; GM-Tg-cang-IP0681-Ab-1/ GM-Tg-cang-IP0681-Ab-2; GM-Tg-bovg-IP0681-Ab-1/ GM-Tg-bovg-IP0681-Ab-2; GM-Tg-equg-IP0681-Ab-1/ GM-Tg-equg-IP0681-Ab-2 |
| Products Name | Anti-DENND5A monoclonal antibody |
| Format | mab |
| Target Name | DENND5A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DENND5A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0681-Ag-1 | Recombinant multi-species DEN5A/ DENND5A/ EIEE49 protein |
Target information
| Target ID | GM-IP0681 |
| Target Name | DENND5A |
| Gene ID | 23258,19347,308942,707945,476844,101085659,784484,100071112 |
| Gene Symbol and Synonyms | 1500012B19Rik,DEE49,DENND5A,EIEE49,mKIAA1091,ORF37,RAB6IP1 |
| Uniprot Accession | Q6IQ26,G3V7Q0 |
| Uniprot Entry Name | DEN5A_HUMAN,DEN5A_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000184014 |
| Target Classification | N/A |
The target: DENND5A, gene name: DENND5A, also named as EIEE49, RAB6IP1. This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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