- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-DERL1 monoclonal antibody
Pre-made anti-DERL1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DERL1/DERL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0683-Ab-1/ GM-Tg-hg-IP0683-Ab-2 | Anti-Human DERL1 monoclonal antibody | Human |
| GM-Tg-rg-IP0683-Ab-1/ GM-Tg-rg-IP0683-Ab-2 | Anti-Rat DERL1 monoclonal antibody | Rat |
| GM-Tg-mg-IP0683-Ab-1/ GM-Tg-mg-IP0683-Ab-2 | Anti-Mouse DERL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0683-Ab-1/ GM-Tg-cynog-IP0683-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DERL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0683-Ab-1/ GM-Tg-felg-IP0683-Ab-2 | Anti-Feline DERL1 monoclonal antibody | Feline |
| GM-Tg-cang-IP0683-Ab-1/ GM-Tg-cang-IP0683-Ab-2 | Anti-Canine DERL1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0683-Ab-1/ GM-Tg-bovg-IP0683-Ab-2 | Anti-Bovine DERL1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0683-Ab-1/ GM-Tg-equg-IP0683-Ab-2 | Anti-Equine DERL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0683-Ab-1/ GM-Tg-hg-IP0683-Ab-2; GM-Tg-rg-IP0683-Ab-1/ GM-Tg-rg-IP0683-Ab-2; GM-Tg-mg-IP0683-Ab-1/ GM-Tg-mg-IP0683-Ab-2; GM-Tg-cynog-IP0683-Ab-1/ GM-Tg-cynog-IP0683-Ab-2; GM-Tg-felg-IP0683-Ab-1/ GM-Tg-felg-IP0683-Ab-2; GM-Tg-cang-IP0683-Ab-1/ GM-Tg-cang-IP0683-Ab-2; GM-Tg-bovg-IP0683-Ab-1/ GM-Tg-bovg-IP0683-Ab-2; GM-Tg-equg-IP0683-Ab-1/ GM-Tg-equg-IP0683-Ab-2 |
| Products Name | Anti-DERL1 monoclonal antibody |
| Format | mab |
| Target Name | DERL1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DERL1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0683-Ag-1 | Recombinant multi-species DERL1/ DER-1/ DER1 protein |
| ORF Viral Vector | pGMLP002287 | human DERL1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002287 | human DERL1 Lentivirus particle |
| ORF Viral Vector | pGMLPm002852 | mouse Derl1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002852 | mouse Derl1 Lentivirus particle |
Target information
| Target ID | GM-IP0683 |
| Target Name | DERL1 |
| Gene ID | 79139,67819,362912,703803,475086,101100445,404121,100057344 |
| Gene Symbol and Synonyms | 1110021N07Rik,DER-1,DER1,DERL1,derlin-1,RGD1311835 |
| Uniprot Accession | Q9BUN8,Q71SS4 |
| Uniprot Entry Name | DERL1_HUMAN,DERL1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136986 |
| Target Classification | N/A |
The target: DERL1, gene name: DERL1, also named as DER-1, DER1, derlin-1. The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
